Yeast programmed cell death and ageing

126.3K

views

65

authors

16

articles

Editorial

18 November 2013

Yeast Programed Cell Death and Aging

Manuela Côrte-Real

and

Frank Madeo

5,870 views

17 citations

Editors

2

Manuela Côrte-Real

University of Minho

University of Graz

Impact

About

Similarly to metazoans, yeast cells can exhibit several characteristics of apoptosis, including chromatin condensation, DNA breakage, flipping of phosphatidylserine to the outer membrane, production of reactive oxygen species, and cytochrome c release from the mitochondria. Yeast programmed cell death has been shown to occur in response to a variety of exogenous stimuli, such as oxidative stress, exposure to acetic acid and expression of mammalian pro-apoptotic proteins. This program is also inherent to the yeast life cycle, as aged mother cells and cells exposed to pheromone also display an apoptotic and necrotic phenotype. We are interested in manuscripts enhancing our understanding on PCD and its deregulation relevant in human pathologies and ageing. These include the identification of previously uncharacterized proteins involved in PCD and ageing, studies involving humanized yeasts, and yeast-based screens for drug discovery.

Similarly to metazoans, yeast cells can exhibit several characteristics of apoptosis, including chromatin condensation, DNA breakage, flipping of phosphatidylserine to the outer membrane, production of reactive oxygen species, and cytochrome c release from the mitochondria. Yeast programmed cell death has been shown to occur in response to a variety of exogenous stimuli, such as oxidative stress, exposure to acetic acid and expression of mammalian pro-apoptotic proteins. This program is also inherent to the yeast life cycle, as aged mother cells and cells exposed to pheromone also display an apoptotic and necrotic phenotype. We are interested in manuscripts enhancing our understanding on PCD and its deregulation relevant in human pathologies and ageing. These include the identification of previously uncharacterized proteins involved in PCD and ageing, studies involving humanized yeasts, and yeast-based screens for drug discovery.

Download ebook

Share

Editors

Manuela Côrte-Real

University of Minho

University of Graz

Impact

126,323 Total views

96,881 Article views

26,875 Article downloads

2,567 Topic views

Published In

Journal Thumbnail

Frontiers in Oncology

Molecular and Cellular Oncology

Journal Thumbnail

Frontiers in Cell and Developmental Biology

Molecular and Cellular Oncology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic