In the complex biological system of higher organisms, the maintenance of metabolic homeostasis requires intricate crosstalk among the different organs that constitute the body. This inter-organ communication allows one tissue to affect metabolic pathways in a distant tissue. Dysregulation of this communication contributes to human pathologies, including obesity, diabetes, liver diseases, and certain cancers. Skeletal muscle plays a central role in glucose homeostasis, namely by secreting myokines, that can contribute to the regulation of metabolic processes in other organs, such as liver and adipose tissue.
This collection aims to shed light onto the complex tissue crosstalk underlying metabolic diseases, specifically obesity and diabetes. It will highlight the latest research exploring such metabolic crosstalk, with a focus on skeletal muscle.
Contributions exploring the regulation of metabolic interactions through diet and exercise, the interaction between the gut microbiome and the host, and tissue dysregulation in obesity and diabetes are examples of areas that will enrich this issue. Studies that use network-based approaches to explore tissue communications relevant to metabolic diseases are welcome. These may be original findings or comprehensive reviews.
This research topic will provide a platform for scientists to share their findings and contribute to a better understanding of the complex interplay between tissues in the context of obesity and diabetes, focusing on the central role of skeletal muscle. We believe that this issue will not only provide novel insights into the pathogenesis of these diseases but also pave the way for the development of precision therapies against various illnesses associated with metabolic dysregulation.
To explore the crosstalk between skeletal muscle, adipose tissue, liver, and other organs, in the development of obesity, insulin resistance, and type 2 diabetes., topics of interest include, but are not limited to:
· Myokines and skeletal muscle function
· Liver and adipose tissue crosstalk interactions
· Adipose tissue and skeletal muscle interaction
· Diet and exercise in metabolic regulation
· Therapeutic interventions targeting skeletal muscle in obesity and diabetes
Keywords: Metabolic, Crosstalk, Skeletal muscle, Obesity, Diabetes
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
