The study of innate immunity, a critical component of the immune system, plays an essential role in identifying and reacting to both pathogenic and non-pathogenic threats, aiming ultimately to repair damaged tissues. This field involves various components such as receptors, molecules, tissues, and especially immune cells—some of which, like MAIT and ILCs, have only recently been identified, while new functions for others, such as NKT and NK cells, continue being discovered. Interestingly, recent studies suggest these cells may also possess memory-like functions. Positioned at strategic locations, these cells are pivotal in defending mucosal surfaces, influencing the composition of local microbiota, and maintaining tissue homeostasis.
This Research Topic aims to highlight cutting-edge research that elucidates the role of innate immune cells in chronic non-transmissible diseases. These diseases, which have reached epidemic proportions globally, involve inflammatory processes where innate immune cells play critical roles from the onset through to the architectural changes in tissues in the later stages. We are particularly interested in contributions that integrate immunology with biochemistry, physiology, and pharmacology to unveil new roles and mechanisms of innate immunity in these diseases. Submissions may range from experimental studies on animal models and human samples to interdisciplinary approaches that include in silico analyses and investigations using non-rodent models.
To gather further insights into these complex interactions, we welcome articles addressing, but not limited to, the following themes:
- Advances in sensing by innate receptors: far beyond pathogen
recognition
- Signaling pathways in sensing by innate receptors
- Uncovering the tissue-specific resident cells
- New roles of new and old innate cells: (re)discovering MAIT, NKT,
ILCs, and NK cells
- Immunometabolism and innate immunity
- Tissue fibrosis and innate immunity
- Memory in innate immunity
We encourage submissions of various types including original research, reviews, case reports, and more, aiming to build a comprehensive understanding of the topic. Please note that studies reliant solely on bioinformatic analysis without relevant experimental validation are considered out of scope.
Topic Editor Renato Monteiro received grants from Moderna, Shire and Biomarin. He is a co-founder of Inatherys. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
The study of innate immunity, a critical component of the immune system, plays an essential role in identifying and reacting to both pathogenic and non-pathogenic threats, aiming ultimately to repair damaged tissues. This field involves various components such as receptors, molecules, tissues, and especially immune cells—some of which, like MAIT and ILCs, have only recently been identified, while new functions for others, such as NKT and NK cells, continue being discovered. Interestingly, recent studies suggest these cells may also possess memory-like functions. Positioned at strategic locations, these cells are pivotal in defending mucosal surfaces, influencing the composition of local microbiota, and maintaining tissue homeostasis.
This Research Topic aims to highlight cutting-edge research that elucidates the role of innate immune cells in chronic non-transmissible diseases. These diseases, which have reached epidemic proportions globally, involve inflammatory processes where innate immune cells play critical roles from the onset through to the architectural changes in tissues in the later stages. We are particularly interested in contributions that integrate immunology with biochemistry, physiology, and pharmacology to unveil new roles and mechanisms of innate immunity in these diseases. Submissions may range from experimental studies on animal models and human samples to interdisciplinary approaches that include in silico analyses and investigations using non-rodent models.
To gather further insights into these complex interactions, we welcome articles addressing, but not limited to, the following themes:
- Advances in sensing by innate receptors: far beyond pathogen
recognition
- Signaling pathways in sensing by innate receptors
- Uncovering the tissue-specific resident cells
- New roles of new and old innate cells: (re)discovering MAIT, NKT,
ILCs, and NK cells
- Immunometabolism and innate immunity
- Tissue fibrosis and innate immunity
- Memory in innate immunity
We encourage submissions of various types including original research, reviews, case reports, and more, aiming to build a comprehensive understanding of the topic. Please note that studies reliant solely on bioinformatic analysis without relevant experimental validation are considered out of scope.
Topic Editor Renato Monteiro received grants from Moderna, Shire and Biomarin. He is a co-founder of Inatherys. The other Topic Editors declare no competing interests with regard to the Research Topic subject.