Tumor metabolomics is an emerging field focused on understanding the metabolic alterations that occur in tumor cells and their surrounding microenvironment. These changes are essential to support the rapid proliferation and survival of cancer cells. Metabolic reprogramming in tumor cells reshapes signaling pathways and influences transcriptional regulation. Furthermore, metabolites within the tumor microenvironment can significantly affect immune cell function, contributing to immune evasion and tumor progression. Integrating transcriptomic, proteomic, and metabolomic data has enabled researchers to map associations between transcriptional regulators and metabolites, offering insights into the complexity of tumor metabolism. Tumor metabolomics holds promise for advancing cancer research, with applications in diagnosis, monitoring, and therapy. Innovative approaches, including the integration of Traditional Chinese Medicine (TCM) and advanced drug delivery systems, are being explored to modulate tumor immunity and metabolism, offering new therapeutic avenues for tumor intervention. Understanding these metabolic processes is key to improving treatment strategies and outcomes for cancer patients.
This Research Topic focuses on the investigation of metabolic alterations associated with tumor metabolic and the development of targeted therapies based on these insights. We invite contributions that explore the following themes: Molecular Mechanisms, Metabolomics and Systems Biology, Therapeutic Approaches. We welcome original research articles, reviews, and perspectives that advance our understanding of tumor metabolic and offer innovative solutions. Manuscripts should provide clear scientific evidence and adhere to rigorous standards of methodology and reporting.
This Research Topic welcomes Original Research articles and Reviews focusing on the following subjects:
• oncological metabolism
• novel metabolic genomic discoveries direct mechanistic investigations
• metabolic reprogramming in disease
• metabolic interventions in the management
• metabolic insights into the pathogenesis and treatment
• nutrigenomics
Keywords: tumor metabolomics, microenvironment, metabolic reprogramming, diagnosis, therapy
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
