The field of antimicrobial research is pivotal as microbial resistance to traditional antibiotics continues to rise alarmingly. Inspired by nature's own arsenal, the design and synthesis of natural antimicrobial derivatives have emerged at the forefront of scientific endeavors aimed at combatting drug-resistant strains. These bio-inspired agents not only promise efficacy against tough microbial candidates but also potentially offer reduced side effects and lower ecological impacts. Groundbreaking advancements in synthetic biology, nanotechnology, and computational chemistry have catalyzed the exploration and development of these agents, uncovering new possibilities and challenging existing limitations in the pharmaceutical sciences.

This Research Topic aims to delve into cutting-edge methodologies and innovative approaches in the design and synthesis of natural antimicrobial derivatives to tackle the critical issue of antibiotic resistance. It intends to highlight contributions that extend the frontiers of current technologies through the integration of recent advancements in chemistry, biotechnology, and materials science. Emphasizing multidisciplinary research, this topic will focus on novel biosynthetic pathways, optimization of antimicrobial peptides, the development of bioactive nanocomposites, and predictive computational models for antimicrobial activity, moving towards the goal of creating potent, sustainable antimicrobial solutions.

To gather further insights in the realms of antimicrobial resistance and novel agent synthesis, we welcome articles addressing, but not limited to, the following themes:

Biosynthesis of novel antimicrobial compounds

Optimization and functionalization of antimicrobial peptides

Development of antimicrobial nanomaterials

Computational approaches for the design of bioactive molecules

We also welcome original research articles, reviews, and brief communications that engage with the intricacies of antimicrobial resistance mechanisms and their practical applications, encouraging a comprehensive view of the next generation of antimicrobials.

Are you interested in contributing a manuscript to this Research Topic?

Design and Synthesis of Natural Antibacterial Derivatives