The integration of oral health with systemic health is pivotal, as the mouth provides a unique and accessible biosignature source. This Research Topic delves into the intricate relationship between oral and systemic diseases, viewing the mouth as a potential gateway for disease control and monitoring. Recent studies suggest a bidirectional relationship between oral conditions and systemic diseases, raising pertinent questions about the mouth's role in systemic health monitoring. The current body of literature shows promising evidence of oral biosignatures' potential in reflecting systemic health, yet a comprehensive understanding is still developing. Identifiable gaps exist where biosignatures from oral sources can be thoroughly explored to improve the methodologies of disease prediction and early intervention.

This Research Topic aims to scrutinize how elements within the mouth—such as saliva, biofilm, and other oral tissues—serve as indicators for systemic conditions, offering novel insights into disease mechanisms. By focusing on these unique biosignatures, we aim to answer questions regarding their correlation with systemic health status and ultimately test hypotheses surrounding their efficacy as diagnostic tools. The objective is to foster cross-disciplinary collaborations that merge dentistry and broader health sciences, paving the way for holistic health promotion.

The scope of this topic encompasses a wide range of investigations while being mindful of the complexity of the oral-systemic link. We welcome submissions, including original research, reviews, and various article types, addressing the following themes:

Investigations linking oral and systemic disorders.
- Studies on oral biological materials (biofilm, saliva, crevicular fluid) as disease biosignatures.
- Assessments of common oral risk indicators across all age groups.
- Cross-disciplinary approaches to health promotion using oral biosignatures.
- Mechanistic insights into the transport and synthesis of biosignatures in the oral cavity.

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The Mouth as a Diagnostic Window: Unveiling the Systemic Implications of Oral Health