Due to the remarkable success of the Research Topic 'Unraveling inflammaging : A pathway to Prevent Age-related Disease in Animals' and the rapidly evolving subject area, we are pleased to launch Volume II for this topic.

The field of age-related diseases in animals, particularly focusing on the concept of 'inflammaging', forms the basis of this research topic. Inflammaging, a term coined to describe the chronic proinflammatory state often associated with aging, has been linked to a variety of degenerative diseases. This low-grade chronic inflammatory state is believed to result from an accumulation of damaged macromolecules and cellular debris due to increased production and inhibited damage surveillance and repair functions in multiple tissues. The secretion of proinflammatory cytokines from senescent cells, known as the 'senescence-associated secretory phenotype' (SASAP), is thought to contribute to the onset of inflammaging. In animals such as dogs and cats, the longer they live, the more diseases they develop, similar to humans, with inflammaging being a potential cause of various age-related diseases.

The primary aim of this research topic is to delve deeper into the mechanisms of inflammaging in animals and its role in age-related diseases. The goal is to develop new diagnostic biomarkers for inflammaging, which could potentially lead to early diagnosis and prevention of age-related diseases. In an aging society, the increase in age-related diseases is inevitable. However, the extension of healthy life years and the ability to stay healthy until old age are standard medical requirements. Therefore, the early diagnosis of inflammaging could be a significant step towards preventing various age-related diseases in animals.

The scope of this research topic is twofold. Firstly, it aims to understand the onset mechanism of inflammaging in animals. Secondly, it seeks to develop new diagnostic biomarkers for inflammaging. The research topic welcomes articles addressing, but not limited to, the following themes:

- Onset mechanism of inflammaging in animals
- Development of new diagnostic biomarkers for inflammaging in animals
- Early diagnosis of age-related diseases with inflammaging in animals
- New treatments (diet therapy, pharmacotherapy, regenerative medicine and others) for age-related diseases in animals.

This research topic also considers the critical role diet plays in either exacerbating or mitigating the inflammatory state associated with aging. Nutrition is a key factor that can influence the degree of inflammaging through various mechanisms, including the modulation of gut microbiota, antioxidant intake, and fatty acid profiles. Proper nutritional strategies could potentially attenuate the proinflammatory environment by enhancing the body's ability to counteract oxidative stress and improving metabolic health. Investigating the impact of specific nutrients, dietary patterns, and feeding regimes on the onset and progression of inflammaging can provide valuable insights, leading to the development of dietary interventions aimed at promoting healthier aging in animals. Thus, this research topic intends to bridge the gap between animal nutrition and inflammaging, contributing to the broader understanding of how dietary factors affect age-related inflammatory processes and overall healthspan in animals.

All types of articles will be considered for publication, including case reports, original research articles, and reviews.

Are you interested in contributing a manuscript to this Research Topic?

Unraveling inflammaging : A pathway to Prevent Age-related Disease in Animals - Volume II