Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses

155.2K

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135

authors

21

articles

Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses

155.2K

views

135

authors

21

articles

Editorial

17 April 2019

Editorial: Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses

Shrikant R. Mulay

,

Martin Herrmann

,

Rostyslav Bilyy

,

Alexander Gabibov

and

Hans-Joachim Anders

3,039 views

8 citations

Editors

5

Hans-Joachim Anders

Ludwig Maximilian University of Munich

Shrikant R Mulay

AstraZeneca (United Kingdom)

Martin Herrmann

University Hospital Erlangen

Rostyslav Bilyy

Danylo Halytsky Lviv National Medical University

Alexander G. Gabibov

Institute of Bioorganic Chemistry (RAS)

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Nano- and microparticles including crystals, synthetic biomaterials, misfolded proteins or environmental particulates are involved in a wide range of biological processes and diseases. They may present as intrinsic or environmental toxins but may also be applied intentionally, e.g. as immune adjuvants, drug carriers or ion exchangers. The discovery that a wide range of nano- and microparticles share the capacity to induce IL-1ß secretion via activation of the NLRP3 inflammasome in dendritic cells and macrophages has led to the hypothesis that nano- and microparticles may contribute in a uniform mechanistic manner to different disease entities. Other molecular mechanisms triggered by a range nano- and microparticles have also recently been identified including (i) the induction of regulated necrosis; (ii) neutrophil extracellular trap (NET) formation and (iii) foreign body granuloma formation as a mechanism of persistent tissue inflammation and scarring.

Research on the biology of nano- and microparticle handling is currently under intense investigation. The cell type-specific responses of nano- and microparticle exposure deserves careful attention as well as the related secondary responses to these particles that lead to tissue remodeling. The immune system is at the center of these processes in terms of particle clearance, particle-induced cell death and inflammation, thereby limiting particle-related inflammation and orchestrating wound healing responses.

In this Research Topic, we welcome the submission of Original Research, Review and Mini-Review articles that will address the significance of the immune system in particle-induced cell death, inflammation and immune responses. These findings will help facilitate new approaches to the prevention and management of particle-related diseases.

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Editors

Hans-Joachim Anders

Ludwig Maximilian University of Munich

Shrikant R Mulay

AstraZeneca (United Kingdom)

Martin Herrmann

University Hospital Erlangen

Rostyslav Bilyy

Danylo Halytsky Lviv National Medical University

Alexander G. Gabibov

Institute of Bioorganic Chemistry (RAS)

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Published In

Frontiers in Immunology

Inflammation, Molecular Innate Immunity, Inflammation Pharmacology

Frontiers in Pharmacology

Inflammation Pharmacology

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