Organoid intelligence represents a novel intersection of biological sciences and computational technology, utilizing human-derived organoids for advanced biocomputing applications. These organoids, particularly those replicating brain functions, exhibit neural activities and responses to various stimuli, laying a fertile ground for data-driven exploration. The combination of real-time electrophysiology, optical interfacing, and chemical stimulation with data science advances permits unprecedented studies into the electrophysical properties of organ tissues. As researchers continue to intertwine stem cell-derived organoids with sophisticated electrophysiological techniques, the potential to drastically enhance our comprehension of neurological functionalities and disorders expands, pushing the boundaries of both medical insights and biocomputing capabilities.

This Research Topic aims to explore and share innovative data science approaches that are shaping the organoid intelligence field. The primary objective is to elucidate the role of data-centric methodologies in navigating and interpreting the complexities of organoid-derived data, which are often voluminous and intricate. By spotlighting cutting-edge tools and techniques, this issue aspires to set foundational paradigms for handling, analyzing, and modeling data that encapsulate organ functions in ways previously unimagined, advancing both theoretical and practical understandings of organoid potential.

To gather further insights, this issue will emphasize:

- Effective management of data acquisition, storage, analysis, and dissemination practices within the organoid research framework.
- We welcome articles addressing, but not limited to, the following themes:
- Designing and executing study frameworks tailored to organoid functionalities
- Developing and implementing novel computational models and algorithms to analyze neural activity data
- Quantifying organoid learning and functionality through innovative metrics
- Challenges and solutions in integrating data science with biological modeling

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Integrating Data Science with Organoid Research for Advanced Biocomputing