Research Topic

Epigenetic Mechanisms Regulating Neural Plasticity

About this Research Topic

Neural plasticity is a unique and adaptive feature of the nervous system that allows neurons to reorganize their interactions in response to stimuli (intrinsic or extrinsic) in order to maintain their function. Several extrinsic factors can alter neural functioning in organisms during their life (from embryonic development, through early development, and until aging): diet (ingestion of nutrients but also nutraceuticals like resveratrol, and chemicals like ethanol), exercise, environmental aspects (such as environmental enrichment during early development, but also the exposure to contaminants present in the environment), stressors (inducing stress-response reprograming), etc.

All of these stimuli exert their effect through some common molecular mechanisms that can be grouped together as “Epigenetic mechanisms,” involving certain molecular signaling pathways like DNA methylation, histone acetylation and deacetylation, the sirtuin pathway, and NF-κB. Therefore, epigenetic mechanisms play an important role in neural plasticity.

This Research Topic seeks to gather high-quality original research papers and review articles addressing recent advances focused on epigenetic mechanisms that influence neural plasticity, and will focus on new insights into cellular and molecular neurobiological mechanisms that underlie brain functioning by correlating the epigenetic regulation of neural plasticity. Potential topics include, but are not limited to:

 Activity-dependent synaptic plasticity (epigenetically modulated)
 The effects of environmental enrichment on neural plasticity
 Responses to stress and effects on neural plasticity
 The effects of Perinatal Reprogramming on neural plasticity
 Epigenetic modifications of neural plasticity during aging
 Epigenetics and neural plasticity
 Dynamics of epigenetic effects during neural development
 Epigenetic regulation of neural plasticity
 Drugs that affect neural plasticity
 The effects of physical activity and exercise on neural plasticity
 The clinical relevance of epigenetic modifications on neural plasticity
 The potential epigenetic impact of environmental factors on neurodevelopmental plasticity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Neural plasticity is a unique and adaptive feature of the nervous system that allows neurons to reorganize their interactions in response to stimuli (intrinsic or extrinsic) in order to maintain their function. Several extrinsic factors can alter neural functioning in organisms during their life (from embryonic development, through early development, and until aging): diet (ingestion of nutrients but also nutraceuticals like resveratrol, and chemicals like ethanol), exercise, environmental aspects (such as environmental enrichment during early development, but also the exposure to contaminants present in the environment), stressors (inducing stress-response reprograming), etc.

All of these stimuli exert their effect through some common molecular mechanisms that can be grouped together as “Epigenetic mechanisms,” involving certain molecular signaling pathways like DNA methylation, histone acetylation and deacetylation, the sirtuin pathway, and NF-κB. Therefore, epigenetic mechanisms play an important role in neural plasticity.

This Research Topic seeks to gather high-quality original research papers and review articles addressing recent advances focused on epigenetic mechanisms that influence neural plasticity, and will focus on new insights into cellular and molecular neurobiological mechanisms that underlie brain functioning by correlating the epigenetic regulation of neural plasticity. Potential topics include, but are not limited to:

 Activity-dependent synaptic plasticity (epigenetically modulated)
 The effects of environmental enrichment on neural plasticity
 Responses to stress and effects on neural plasticity
 The effects of Perinatal Reprogramming on neural plasticity
 Epigenetic modifications of neural plasticity during aging
 Epigenetics and neural plasticity
 Dynamics of epigenetic effects during neural development
 Epigenetic regulation of neural plasticity
 Drugs that affect neural plasticity
 The effects of physical activity and exercise on neural plasticity
 The clinical relevance of epigenetic modifications on neural plasticity
 The potential epigenetic impact of environmental factors on neurodevelopmental plasticity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

06 February 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

06 February 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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