Urinary system diseases hold significant public health importance due to their high prevalence, impact on patients' quality of life, and the increased healthcare burden they impose. These diseases are closely associated with chronic conditions such as cardiovascular diseases and diabetes, highlighting issues of health disparities. Although the mechanisms underlying urinary system diseases are complex and not yet fully understood, genetic factors play a crucial role in research, aiding in the understanding of disease pathogenesis, guiding personalized treatment approaches, and contributing to the development of new therapies.

We hope your article will provide a detailed exploration of how related genes and their variations contribute to diseases such as renal cancer, urinary tract infections, bladder cancer, and urolithiasis, revealing the specific pathological mechanisms involved in these processes. The article should cover the molecular pathways associated with these diseases, including gene mutations, dysregulated gene expression, gene-environment interactions, and their impact on clinical manifestations. Additionally, we encourage you to discuss recent advances in genetic research related to urinary system diseases and how these developments offer new perspectives for personalized medicine and targeted therapy. Through this article, we aim to provide a deep theoretical foundation for the field and promote the development of early diagnosis and precision treatment strategies for urinary system diseases.

We welcome discussions covering, but not limited to, the following aspects.

● Molecular epidemiology reveals the biological mechanisms of urinary system diseases.
● Development of bioinformatics algorithms for genomics of urinary system diseases.
● Identifying novel genetic loci for urinary system diseases.
● Other genetic mechanisms in the development of urinary system diseases.
● Application of integrative multi-omics approaches in the mechanisms of urinary system diseases.

Please Note: Descriptive studies (e.g. gene expression profiles, or transcript, protein, or metabolite levels under particular conditions or in a particular cell type) and studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic data do not fall within the scope of the journal and will not be considered for publication unless they are expanded and provide significant biological or mechanistic insight into the process being studied.

Are you interested in contributing a manuscript to this Research Topic?

Genetics in the Onset and Progression of Urinary System Diseases: Pathological Role and Molecular Mechanism