The prevalence of diabetes, cardiovascular, and cerebrovascular diseases has reached alarming levels worldwide, posing significant challenges for healthcare and economic systems. Traditional treatments for these chronic conditions often involve pharmacological interventions, which, though effective, can come with a range of side effects and substantial economic costs. This has sparked a growing interest in alternative, complementary approaches, particularly those derived from natural sources, including food-derived bioactive compounds and endogenous metabolites. These compounds, which include vitamins, minerals, polyphenols, and other phytochemicals, have shown promise in the prevention and management of diabetes, cardiovascular, and cerebrovascular diseases through various mechanisms with minimal side effects. These mechanisms include the modulation of inflammation, oxidative stress, immune reactions, and metabolic pathways. Understanding these mechanisms could provide novel therapeutic targets for treating these diseases simultaneously.

This Research Topic aims to gather cutting-edge research on the therapeutic potential of food-derived bioactive compounds and endogenous metabolites in the context of diabetes, cardiovascular, and cerebrovascular diseases. We welcome studies that explore how these compounds can influence glucolipid metabolism, inflammation, oxidative stress, and immune reactions—critical factors in the development and progression of these conditions. By elucidating the mechanisms through which food-derived bioactive compounds and endogenous metabolites exert their beneficial effects, this Research Topic seeks to bridge the gap between nutritional science and the clinical applications of effective therapeutic strategies. Collaborative efforts between neuroscientists, endocrinologists, cardiologists, pharmacologists, and researchers across disciplines are critical to unraveling the complexities of these conditions and translating scientific discoveries into clinical practice. The pursuit of innovative treatments and preventative measures promises to enhance healthy dietary behavior and improve the quality of life in these populations.

Submissions may include, but are not limited to, the following themes:
• Nutritional Biochemistry: Insights into how natural compounds play roles in maintaining metabolic health and how their effects can be enhanced through diet.
• Molecular Mechanisms: Studies investigating the molecular pathways influenced by natural compounds.
• Clinical Trials and Epidemiological Studies: Research that provides clinical evidence for the efficacy of bioactive compounds in the prevention or treatment of diabetes and cardiovascular and cerebrovascular diseases.
• Nutrigenomics: Investigations on how bioactive compounds influence gene expression and how these changes translate to metabolic health benefits.
• Formulation and Delivery: Innovative approaches to incorporating bioactive compounds into functional foods or supplements to maximize their bioavailability and therapeutic efficacy.
• Concurrent Risk Factors: Exploration of how natural compounds can mitigate concurrent risk factors such as obesity, dyslipidaemia and related diseases.
• Public Health and Policy: Studies that evaluate the role of diet rich in bioactive compounds in public health strategies.

Are you interested in contributing a manuscript to this Research Topic?

Therapeutic Potential of Food-Derived Bioactive Compounds and Endogenous Metabolites for Diabetes, Cardiovascular, and Cerebrovascular Diseases