In the rapidly evolving field of tissue engineering, the development of functional biomaterials and seed cells holds transformative potential for repairing severe tissue defects. These biomaterials, as pivotal elements, are engineered to deliver essential biological molecules including growth factors and extracellular matrix components, while also possessing unique properties that allow them to respond to physiological stimuli such as light and heat. Combined with seed cells, these materials can create organoids crucial for enhancing tissue repair, demonstrating capabilities such as energy metabolism regulation and targeted tissue regeneration. Despite considerable advances in understanding disease mechanisms and tissue regeneration, continued research is needed due to the complex interactions between biomaterials, seed cells, and living systems, which can yield unpredictable results.This Research Topic aims to curate a comprehensive collection of articles exploring the cutting-edge developments, ongoing challenges, and future directions in the use of functional biomaterials and seed cells within tissue engineering and regenerative medicine. By publishing full-length research articles, short communications, reviews, and opinions, this topic seeks to foster a deeper understanding of the design, synthesis, and application of these innovative materials.To gather further insights in the realm of biomaterials and cellular interactions, we welcome articles addressing, but not limited to, the following themes:• Design, preparation, and characterization of functional biomaterials and seed cells in tissue engineering• Cell-Biomaterials interaction at the nanoscale and microscale.• Design of smart carrier, scaffold, and hydrogel materials.• Biofabrication techniques• Combining cells/signaling with functional and smart biomaterials for guided tissue regeneration• Mechanisms of cell-biomaterials interaction
In the rapidly evolving field of tissue engineering, the development of functional biomaterials and seed cells holds transformative potential for repairing severe tissue defects. These biomaterials, as pivotal elements, are engineered to deliver essential biological molecules including growth factors and extracellular matrix components, while also possessing unique properties that allow them to respond to physiological stimuli such as light and heat. Combined with seed cells, these materials can create organoids crucial for enhancing tissue repair, demonstrating capabilities such as energy metabolism regulation and targeted tissue regeneration. Despite considerable advances in understanding disease mechanisms and tissue regeneration, continued research is needed due to the complex interactions between biomaterials, seed cells, and living systems, which can yield unpredictable results.This Research Topic aims to curate a comprehensive collection of articles exploring the cutting-edge developments, ongoing challenges, and future directions in the use of functional biomaterials and seed cells within tissue engineering and regenerative medicine. By publishing full-length research articles, short communications, reviews, and opinions, this topic seeks to foster a deeper understanding of the design, synthesis, and application of these innovative materials.To gather further insights in the realm of biomaterials and cellular interactions, we welcome articles addressing, but not limited to, the following themes:• Design, preparation, and characterization of functional biomaterials and seed cells in tissue engineering• Cell-Biomaterials interaction at the nanoscale and microscale.• Design of smart carrier, scaffold, and hydrogel materials.• Biofabrication techniques• Combining cells/signaling with functional and smart biomaterials for guided tissue regeneration• Mechanisms of cell-biomaterials interaction