About this Research Topic
Tremendous progress over the last decade has been made in defining pivotal roles for the microbiome in the regulation of neurological disease progression, neuroimmunology, brain function, and neurodevelopment. The study of the gut-brain axis has emerged as one of the most fast-paced and exciting areas in all of neuroimmunology and neuroscience research. Research on the gut-brain axis has recently reached a key inflection point where studies have gone from solely identifying roles for microbiota in brain health and disease, to now delving into the discrete biological processes that account for the effects of commensal microbes on the brain. In particular, recent evidence suggests that the immune system serves as a primary nexus of communication between microbiota and the brain.
In this Research Topic, we welcome the submission of Reviews from leaders in the field to provide a comprehensive and unbiased overview of seminal discoveries and prevailing concepts that have guided gut-immune-brain axis research. We seek and encourage articles that cover a broad range of topics including the impact of the microbiome on mental illness, cognition, neurodevelopment, behavior, and various forms of neuroinflammatory, psychiatric, and neurodegenerative disease. We welcome the submission of Original Research articles, Reviews and Mini-reviews that discuss ways in which the microbiome mechanistically influences brain biology (e.g, regulation of periphery immune responses, neural communication, HPA axis, neurotransmitter production, etc.).
We have only just skimmed the surface in understanding how the immune system coordinates reciprocal crosstalk between the microbiome and the brain, and many exciting and important areas investigation still remain. Therefore, we also encourage the submission of Perspective and Commentary articles that aim to discuss important unresolved questions in the field research and to also provide thought-provoking ideas that will serve to guide future discussion and gut-immune-brain axis research.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.