Biomarker research in dentistry is an emerging field that holds significant promise for transforming diagnostic and therapeutic approaches in oral health. Despite advancements in dental care, there remain substantial gaps in early detection and personalized treatment of oral diseases. Current research has identified various biomarkers, such as proteins, nucleic acids, and metabolites, that can be measured to indicate biological processes and disease states. Recent studies have shown the potential of saliva-based biomarkers in diagnosing conditions like periodontal diseases, caries, and oral cancers. However, the field still faces challenges in the efficient extraction and analysis of these biomarkers, and there is a need for more comprehensive studies to validate their clinical utility. Addressing these gaps could lead to more precise and individualized dental care, ultimately improving patient outcomes.

This research topic aims to delve into the potential of molecular signatures in dentistry, focusing on the identification, validation, and application of biomarkers in oral health. We seek to answer critical questions about the role of genetic and salivary biomarkers in diagnosing and treating dental diseases. By testing hypotheses related to the interplay between genetic factors and environmental influences, we aim to pave the way for personalized treatment strategies. Our objective is to gather a diverse range of studies that will contribute to a deeper understanding of how biomarkers can revolutionize dental diagnostics and therapeutics.

To gather further insights into the boundaries of biomarker research in dentistry, we welcome articles addressing, but not limited to, the following themes:
- Blood and Saliva-Based Biomarkers:
- Identification and validation of specific proteins, nucleic acids, and metabolites in saliva indicative of various oral conditions, such as pulp and periodontal diseases, caries, and oral cancers.
- Technological advancements and methodologies for the efficient extraction and analysis of salivary biomarkers.
- Genetic Markers in Dental Diseases:
- Exploration of genetic markers associated with endodontic disease, orthodontic problems, enamel defects, temporomandibular disorders, and their interplay with epigenetics.
- Insights into the interplay between genetic factors and environmental influences, to pave the way for personalized treatment strategies based on an individual's genetic profile.

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Molecular Signatures in Dentistry: Transforming Oral Health Diagnostics and Therapeutics