About this Research Topic
Although much progress has been made, many questions still remain to be addressed. For example, the complexity of the DC compartment could be explored for the identification of better DC subsets to target for therapeutic applications. The potential manipulation and use of DCs, or their subtypes, in vaccination protocols is currently being addressed in clinical trials, especially in cancer patients. Exploring the different functions of DCs in complex settings in relation to immunity and tolerance is essential for our understanding of how our immune system deals with infections and maintains homeostasis. Such knowledge may be used not only to improve our understanding of immune system function, but also in vaccine design and in the treatment of autoimmune diseases.
In this Research Topic, we welcome the submission of Original Research, Methods, Protocols, Classification, Reviews, Mini-Reviews, Perspective and Clinical Trial articles that cover recent advances in the following topics:
1. DC ontogeny.
2. DC subsets and their regulation of immune function.
3. DC receptors and antigen recognition.
4. DC antigen processing machinery.
5. DC activation in the context of infection and/or inflammation.
6. DC regulation of peripheral tolerance.
7. DC interactions with T and/or B cells.
8. Mouse models used to study dendritic cell biology and function.
9. Vaccination strategies using dendritic cells.
Keywords: Dendritic cells, Immunity, Immune tolerance
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.