In the last two decades, the increased knowledge about the mechanisms underlying the process of malignant transformation and the improved techniques in DNA sequencing have allowed the identification of many genes that, in the presence of pathogenic mutations, increase the risk of developing gynecological cancer. The most famous examples are the BRCA-associated ovarian cancer and the MMR gene mutations responsible for Lynch syndrome, which includes endometrial cancer. However, mutations to many other genes, less frequently reported, are responsible for increased cancer risk.

These findings are of utmost importance because carriers of these mutations might undergo intensive screening and/or primary prevention, and this could have a positive effect on the health status of these subjects and also an impact on the health system, sparing the treatment of many cancer cases. However, since the knowledge in this field is relatively recent and due to both the relatively low frequency of these mutations in the population and the lack of genetic screening programs, the identification of these high-risk individuals is challenging, and the management is object of debate in the scientific community.

In this Research Topic, we encourage primarily the submission of Original Research, Case Report or Review articles that focus on, but are not limited to:

- Effect of pathogenic mutations on the risk of gynecological cancer
- Strategies for the identification of carriers of genetic mutations
- Management of high-risk healthy individuals

We also will consider, in this Research Topic, papers on the relationship between genetic mutations and the therapeutic effect of anticancer drugs.

Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.

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Gynecological Cancer Prevention in Women with Inherited Genetic Risk