The remarkable adaptability of the nervous system, known as neuroplasticity, plays a crucial role in both normal physiological processes and the development of pathological conditions, including persistent (chronic) pain. Sensitization, a key feature of persistent pain, is often a direct consequence of neuroplastic changes. In this research topic, we explore the intricate relationships between neuroplasticity, sensitization and other measures of pain and its impact, across species, to uncover novel insights and therapeutic opportunities.

Neuroplasticity encompasses the nervous system's ability to reorganize itself by forming new neural connections. This adaptability is essential for learning, memory, and recovery from injuries. It may also be protective from the perspective of heightening an organism’s awareness of its environment and surroundings. However, it can also contribute to chronic pain through maladaptive changes that heighten neuron sensitivity, leading to persistent pain states. Studying neuroplasticity and its varying manifestations across different species provides a broader understanding of these processes and their implications in pain research.

Sensitization can occur at various levels of the nervous system, including peripheral, spinal, and supraspinal sites. Sensitization results from increased facilitation and/ or altered inhibition of pain signals. In animals, sensitization is evident through changes in behavior, locomotion, and other physiological responses, mirroring many aspects of human chronic pain conditions. Sensitization has been measured in a variety of ways, including electrophysiologically, ex vivo and in vivo functional assays, and using quantitative sensory testing.

This Research Topic aims to collect high-quality, interdisciplinary research that addresses the mechanisms, impacts, and implications of neuroplasticity and sensitization across multiple species. We welcome contributions that explore, but are not limited to:

Molecular and cellular mechanisms driving neuroplasticity and sensitization in different species.

Comparative analyses of pain pathways and sensitization effects between humans and animals.

Innovative diagnostic tools and imaging techniques to study neuroplasticity and sensitization in veterinary patients.

The role of genetics, epigenetics, and environmental factors in modulating neuroplasticity and sensitization across species.

Therapeutic approaches aimed at modulating neuroplastic changes to reduce sensitization and chronic pain.

Case studies and clinical trials that enhance our understanding of neuroplasticity-induced sensitization in veterinary practice.

Behavioral studies demonstrating the impact of sensitization on animal welfare, with implications for human health.

By examining neuroplasticity and sensitization in a comparative framework, we aim to inform both veterinary and human pain research. Insights gained from these studies will not only improve pain management strategies for animals but also provide valuable translational knowledge that can benefit human medicine. Understanding these processes across species enriches our overall comprehension of chronic pain and opens new avenues for innovative treatments.

Join us in this exciting exploration of neuroplasticity and sensitization across species. Your contributions will help advance our knowledge of chronic pain mechanisms and foster the development of effective pain management solutions for a wide range of species, enhancing the quality of life.

Are you interested in contributing a manuscript to this Research Topic?

Neuroplasticity and Sensitization Across Species