Research Topic

Perspectives in Small Animal Radionuclide Imaging

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Radionuclide imaging offers a unique opportunity to monitor and quantify biological processes in vivo. The development of specific small-scale machines for either single (microSPECT) or coincidence photon detection (microPET) has expanded the field of application of radionuclide imaging techniques to ...

Radionuclide imaging offers a unique opportunity to monitor and quantify biological processes in vivo. The development of specific small-scale machines for either single (microSPECT) or coincidence photon detection (microPET) has expanded the field of application of radionuclide imaging techniques to preclinical models of diseases. The coupling of small animal scintillation cameras with computed tomography (CT) or magnetic resonance (MR) has fully reproduced the hybrid imaging tools available at human scale.

At the same time, the spectrum of potential targets for imaging and therapy has dramatically broadened, and testing on small animal models has become a must of modern medicine. Nevertheless, small animal models present several challenges, both from a biological and a computational point of view. The uncertainties introduced by genetic manipulation, biological interspecific diversities and differences of organ mass and functioning require deep understanding and troubleshooting to accomplish a successful translation from bench to bedside.

This focused Research Topic is indented to account for the numerous interdisciplinary aspects and challenges of small animal radionuclide imaging, including advancement on hardware and software design, new drug development, computation of pharmacokinetic and radiation dosimetry as well as micro environmental tumor biology.

This Research Topic is launched with Frontiers in Medicine, Nuclear Medicine section and considering the interdisciplinary research we have also opened this Research Topic for submissions in Frontiers sister journals i.e. Frontiers in Oncology, Frontiers in Physics and Frontiers in Physiology.

We believe that this journal platform will give excellent visibility to your papers and we cordially encourage submissions on the topics outlined above.


Keywords: small animal imaging, radiopharmaceuticals, drug development, SPECT and PET detector design, dosimetry


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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