Haemoprotozoan infections, including those caused by species like Plasmodium, Babesia, and Trypanosoma, present significant zoonotic challenges, impacting both human and animal health globally. These parasites are notorious for their complex life cycles and robust defense mechanisms against host immune responses, complicating efforts at control and eradication. The shifting dynamics of these infections and their widespread effects necessitate a deeper understanding of their biology, which remains insufficiently explored in current research. This context underscores the urgent need to elucidate the sophisticated interactions between these pathogens and their hosts, particularly concerning mechanisms of disease pathogenesis.

This Research Topic aims to foster advancements in haemoprotozoan vaccinology by addressing the critical hurdles in developing effective vaccines. Effective immunization against these pathogens is imperative yet stymied by their intricate biological nuances and adeptness at evading immune detection. Specific goals include exploring novel vaccine targets, improving adjuvant formulations, and refining delivery mechanisms, which are pivotal in overcoming the existing challenges in vaccine efficacy against these diseases. Enhancing our understanding of immune responses against haemoprotozoan infections will catalyze the development of efficacious vaccines, propelling the field toward significant breakthroughs.

To gather further insights in overcoming the challenges of haemoprotozoan infections, we welcome articles addressing, but not limited to, the following themes:

-Molecular and cellular mechanisms of pathogen-host interactions
-Advances in genomic and bioinformatic techniques to uncover pathogenic pathways
-Innovative vaccine strategies, including antigen discovery and adjuvant development
-Interdisciplinary research combining environmental science, veterinary medicine, and epidemiology
-Public health strategies and policies for controlling zoonotic spread
-Socio-economic impacts of haemoprotozoan diseases and sustainable intervention strategies

By integrating multiple disciplines, this special issue seeks to pave the way for a consolidated, global approach to managing the burden posed by these intricate infections, aimed at guiding future strategies and public health interventions.

The topic editors declare no conflicts of interest

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Advancing Haemoprotozoan Vaccinology: Interdisciplinary Approaches and Challenges