Mitochondria, traditionally acclaimed as the powerhouses of eukaryotic cells due to their role in ATP synthesis, are increasingly recognized for their broader biological functions. Contemporary studies extend beyond energy production, identifying mitochondria as metabolic integrators and signaling conduits that regulate many biosynthetic pathways across various cell types. Recent explorations have underscored their crucial role in coordinating cellular responses through intricate signaling networks, like calcium homeostasis and programmed cell death, such as apoptosis.

This Research Topic aims to delve into the multifaceted roles of mitochondria in sensing and responding to cellular stresses. It seeks to uncover how disruptions in mitochondrial activities such as oxidative phosphorylation and protein sorting can initiate diverse stress responses-from immediate protein modifications to long-term transcriptional adaptations. Furthermore, the topic will explore the mechanisms through which mitochondria communicate with cellular and extracellular environments, which are crucial for maintaining cellular function and homeostasis.

To gather further insights into these dynamic interactions, articles that address the following themes are especially welcome:

• Mitochondrial roles in programmed cell death and intracellular signaling

• Impact of mitochondrial dysfunctions on cellular stress pathways, including the integrated stress response

• Inter-organellar communication between mitochondria and other cellular compartments via membrane contacts and vesicular trafficking

• Comparative studies on mitochondrial functions in different cellular models, from yeast to mammalian systems

• Novel mechanisms by which mitochondria influence cellular adaptation and survival strategies under stress conditions

This compilation of research topics will significantly enhance our understanding of mitochondria as central players in cellular resilience and adaptation, appealing to various fields within the biomedical sciences.

Are you interested in contributing a manuscript to this Research Topic?

Mitochondria as Integrative Signaling Hubs in Cellular Stress Responses