According to the World Health Organization, approximately one in every third of individuals is affected by neurological diseases, which pose a global health burden. Though recent developments in biology have transformed our understanding of these diseases, we still lack complete knowledge of their underlying pathologies, progression, relapse, and severity. Besides, there is a dearth of reliable biomarkers that could serve as reliable quantifiable indicators of these diseases for accurate clinical diagnosis. Additionally, the identification and characterization of biomarkers could play a pivotal role in predicting disease onset and progression and predicting a favorable therapeutic response.

This research topic aims to further our understanding of neurological diseases and disorders, including neuromalignancies, mood disorders, and neurodegenerative, neurodevelopmental, and neuropsychiatric diseases. Moreover, there is increased skepticism in neuroscience regarding the development and identification of peripheral markers to improve patient compliance and analyze more accessible biofluids to reduce cost and improve the feasibility of diagnosis.

To gather further invaluable insights, we invite manuscripts that comprehensively overview novel biomarkers for neurological disorders. We encourage submissions that enlist new approaches for biomarker discovery as well as detailed validation paradigms. We cordially invite the submission of original articles, reviews, mini-reviews, systematic reviews, methods, and perspectives centred on, but not limited to, the subsequent thematic areas:

1. Discovery, characterization, and validation of biomarkers in neurological disorders for predicting disease onset progression and therapeutic response.

2. Imaging, epigenetics, proteomics, and gene-based biomarkers for central nervous system (CNS) disorders and neuro-malignancies.

3. Harnessing the potential of deep learning and artificial intelligence-based model systems to identify novel CNS disease-specific biomarkers.

4. Biomarker discovery using non-invasively and invasively collected body fluids.

5. Unveiling the therapeutic potential of known biomarkers for neurological disorders.

We wholeheartedly welcome submissions from scientists working with multidisciplinary approaches that potentially overlap in clinical research, immunology, genetics, epigenetics, genomics, pharmacology, molecular biology, and cell biology.

Are you interested in contributing a manuscript to this Research Topic?

Biomarker Discovery and Validation in Neurological Diseases