About this Research Topic
The question remain is, how the KD, glycolytic inhibition and other metabolic manipulations affect seizure activity? The fundamental basis of seizure generation is an increased neural excitability involving a host of cellular mechanisms such as ion channels, membrane properties, receptors, transporters, synaptic transmission and neural networks. Most likely, the anticonvulsive action of metabolic regulation is multifaceted, e.g., the KD may involve KATP channels, ketone bodies, and other mechanisms which lead to reduced neuronal excitability. The anticonvulsive activity by glycolytic inhibition may involve suppression of intrinsic neuronal firing and augmentation of GABAergic synaptic transmission, but the detailed mechanisms are yet to be elucidated. The anticonvulsant action of F1,6BP on animal models are remarkable yet the mechanisms of action are largely unknown. Moreover, metabolic manipulation may alter the process of epileptogenesis and produce antiepileptic effect through a variety of mechanisms. In addition to neuronal metabolism, glial cell metabolism may be also important for seizure generation (via “astrocyte-neuron lactate shuttle”). Elucidation of the action and mechanisms of metabolic manipulation would not only lead to new knowledge and better understanding regarding metabolic state and neuronal excitability and seizure control, but also hold the promise as a novel treatment of drug-resistant seizures and epilepsy prevention.
In summary, the field of cell metabolism on neural excitability and epilepsy is relatively new and under-explored, yet the emerging research in this field has begun to provide novel and exciting results on regulating neural excitability and controlling seizures from a unique perspective, which is both scientifically interesting and clinically important.
Keywords: Energy metabolism, Glycolysis, Neural excitability, Seizure, Electrophysiology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.