About this Research Topic
Immune-inflammation is a complex cascade around affected tissues in response to pathological stimuli. This cascade consists of both immune disorders and inflammatory responses that determine the progress of tissue wound healing. Recent studies have established the link of immune-inflammation to the pathogenesis of many common inflammatory and immunological diseases.
Despite extensive efforts towards primary prevention, cardiovascular diseases are yet the leading cause of death in the world and one of the first causes of disability. Numerous studies have shown a tight link between immune-inflammation and pathogenesis of cardiovascular diseases, such as myocardial infarction, heart failure, atherosclerosis, hypertension, and other cardiometabolic disorders.
Throughout history, compounds derived from natural sources have demonstrated their prowess as therapeutic agents in areas such as inflammation, cardiovascular diseases, et al. It is estimated that approximately 25–50% of marketed drugs today owe their origins to natural products. Meanwhile, recent evidence has highlighted that a number of natural compounds were under development for modulating immune and cardiovascular homeostasis.
In this Research Topic, we welcome investigators to contribute original research articles reporting data from both experimental and clinical studies, as well as review articles that provide a better understanding of modulatory effects and underlying mechanisms of natural compounds on inflammatory, immunological or cardiovascular diseases. It should be noted that an accurate chemical and quantitative characterization of active compounds in the extracts is required. In addition, the studies of active compounds in humans should be performed using the clinical trials procedure. In addition, basic research on immunomodulatory or cardiovascular homeostatic mechanisms in these diseases are also welcome.
Keywords: Natural Compounds, Immunomodulation, Cardiovascular Disease, Molecular Mechanisms, Signaling Pathway
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.