Aging is marked by significant alterations in the immune system, known as immunosenescence, and in metabolic functions, termed metabolic reprogramming. These changes are intricately linked to the development and progression of age-related diseases. Immunosenescence involves deteriorated immune surveillance, chronic low-grade inflammation ("inflammaging"), and an elevated risk for infections, autoimmune diseases, and cancers. Concurrently, metabolic reprogramming in aging is characterized by changes in energy balance, mitochondrial dysfunction, and shifts in nutrient-sensing pathways, contributing to metabolic disorders like cardiovascular disease, diabetes, and neurodegeneration. This complex interplay between immune and metabolic processes in aging underlines the need for comprehensive studies to uncover their roles in age-related pathologies.

This Research Topic aims to enhance our understanding of the dual phenomena of immunosenescence and metabolic reprogramming in aging and age-related diseases, with a focus on unraveling the mechanisms at play and investigating potential therapeutic targets. We aspire to bridge gaps in knowledge regarding how these processes evolve with age and how they can be manipulated to treat or prevent age-associated diseases. The inclusion of emerging technologies and interdisciplinary approaches in research is crucial to advancing this field.

To advance the understanding and therapeutic potential in this field, we welcome contributions that cover, but are not limited to, the following themes:
• Mechanistic studies on the decline of adaptive and innate immune functions and changes in immune cell phenotypes, including T cell exhaustion and NK cell dysfunction with aging.
• Investigations into immune signatures and biomarkers linked to aging and age-related disorders.
• Impact of metabolic dysregulation on cellular senescence and overall tissue function in aging bodies.
• Studies on the role of metabolic biomarkers in aging and their correlation with disease risks.
• Exploration of how immune dysfunction intersects with metabolic dysregulation during aging.
• Development of targeted therapies that address immunosenescence and metabolic reprogramming.

Are you interested in contributing a manuscript to this Research Topic?

Immunosenescence and Metabolic Reprogramming in Aging: Mechanistic Insights and Interventions