This Research Topic delves into the complex biology of inflammasomes, their roles in immune responses, and their contribution to inflammatory disorders. It aims to provide comprehensive insights into "Exploring the Biology of Inflammasomes: Mechanisms, Disorders, and Therapeutic Potential", aimed at advancing our understanding of inflammasomes and their pivotal roles in immune regulation, inflammation, and disease pathology. This comprehensive collection invites innovative contributions that explore the intricate biology of inflammasomes, their dysregulation in disease, and their applications in diagnostics and therapeutics, with a special emphasis on translational and clinical research.

Inflammasomes are central mediators of innate immunity, acting as molecular platforms that detect pathogenic and damage-associated signals, activate inflammatory cytokines such as IL-1β and IL-18, and induce pyroptotic cell death. While they play protective roles in host defense, their dysregulation has been implicated in various diseases, including chronic inflammatory disorders, infectious diseases, oncology, and transplantation medicine. This Research Topic aims to provide a platform for discussing the latest advancements in these areas and fostering innovative therapeutic approaches.

The key areas of focus include but not limited to:

Therapeutic Strategies Targeting Inflammasomes
- Highlighting advances in drug discovery, including small-molecule inhibitors, biologics, and gene-based approaches targeting inflammasomes.
- Evaluating the preclinical and clinical efficacy of emerging therapies aimed at modulating inflammasome activity in inflammatory and immune-mediated diseases.

Translational Research and Clinical Implications
- Bridging basic research with clinical applications by investigating the diagnostic and prognostic value of inflammasome activity in diverse diseases.
- Exploring precision medicine approaches informed by inflammasome biology for individualized patient care.
- Translating findings into actionable therapeutic strategies for inflammation-related diseases.

Topic Editor Dr. Seong is CEO and Founder of Shaperon Inc. and Founder of Hudson Therapeutics Inc. The other Topic Editor has no conflict of interest to declare with respect to the Research Topic.

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Exploring the biology of inflammasomes: Mechanisms, disorders, and therapeutic potential