Research Topic

Targeted Subcellular Delivery of Anti-Cancer Agents

About this Research Topic

Anti-cancer pharmaceuticals that are practical to be delivered into specific subcellular compartment could be divided into at least two groups. The first comprises substances that show their effects only when delivered to a certain cell compartment, like DNA in the nucleus. There is a growing interest in targeted subcellular delivery of such biologically active biopolymers as transcription factors and antibodies which reveal their biological effects within specific cell compartments. Approaches to DNA delivery are widely discussed, whereas delivery of the above biopolymers remains underestimated. The second group includes antitumor medicines capable of cytotoxic effects in any part of the cell; however, one can find a cell compartment most sensitive to their effects. In other words, there are compartments in which localization requires the minimum doze of a cytotoxic drug to kill the cell. Examples of such substances are photosensitizers, radionuclides emitting short-range particles (like alpha-particle- or Auger-electron emitters).

There will be 4 areas covered by this journal issue :
1. Very concise descriptions of molecular mechanisms of intracellular transport used (or can be used) for subcellular delivery of clinically relevant “cargoes”.
2. Papers describing reasons why certain groups of anti-cancer agents should be delivered into specific subcellular compartments.
3. Papers describing different approaches to nuclear delivery of anti-cancer agents.
4. Delivery into different cytoplasmic structures


Keywords: subcellular drug delivery, intracellular transport, cell nucleus, anti-cancer agents, cell compartments


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Anti-cancer pharmaceuticals that are practical to be delivered into specific subcellular compartment could be divided into at least two groups. The first comprises substances that show their effects only when delivered to a certain cell compartment, like DNA in the nucleus. There is a growing interest in targeted subcellular delivery of such biologically active biopolymers as transcription factors and antibodies which reveal their biological effects within specific cell compartments. Approaches to DNA delivery are widely discussed, whereas delivery of the above biopolymers remains underestimated. The second group includes antitumor medicines capable of cytotoxic effects in any part of the cell; however, one can find a cell compartment most sensitive to their effects. In other words, there are compartments in which localization requires the minimum doze of a cytotoxic drug to kill the cell. Examples of such substances are photosensitizers, radionuclides emitting short-range particles (like alpha-particle- or Auger-electron emitters).

There will be 4 areas covered by this journal issue :
1. Very concise descriptions of molecular mechanisms of intracellular transport used (or can be used) for subcellular delivery of clinically relevant “cargoes”.
2. Papers describing reasons why certain groups of anti-cancer agents should be delivered into specific subcellular compartments.
3. Papers describing different approaches to nuclear delivery of anti-cancer agents.
4. Delivery into different cytoplasmic structures


Keywords: subcellular drug delivery, intracellular transport, cell nucleus, anti-cancer agents, cell compartments


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

31 January 2018 Abstract
30 May 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

31 January 2018 Abstract
30 May 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top