Inflammation and immunity are fundamental pillars of cancer biology, playing dual roles that can either promote or inhibit tumor progression. Chronic inflammation significantly contributes to cancer initiation, development, and metastasis, fostering an environment that supports cell proliferation, immune evasion, and therapeutic resistance. Simultaneously, the immune system, although a natural defense against malignancy, can be reprogrammed to aid tumor growth. Recent advances have enhanced our understanding of the interactions between inflammation and immunity in the oncological context, highlighting the impact of cytokines, chemokines, immune cells, and the microbiota on cancer progression. This Research Topic aims to broaden the knowledge of these dynamic interactions and their therapeutic implications, promoting a multidisciplinary perspective that spans from basic research to clinical application.

Cancer treatment continues to face significant challenges due to the heterogeneity of the tumor microenvironment and the complexity of inflammatory and immune responses. Understanding the molecular and cellular basis of these processes can pave the way for more effective and personalized therapies. This Research Topic aims to address these interactions from multiple angles, encouraging studies that explore novel therapeutic targets, mechanisms of resistance, and the integration of tools such as immunotherapy, modulation of inflammatory pathways, and tumor microenvironment remodeling. It also seeks to promote innovative research in emerging areas, including the role of the microbiota, systemic inflammation in cancer patients, and combination therapies that unite anti-inflammatory and immunological strategies.

We invite studies highlighting recent advances in technologies such as genetic editing, bioinformatics for tumor microenvironment analysis, and biomarker validation for patient stratification. This broad approach aims to foster interdisciplinary collaborations and facilitate the participation of researchers from diverse fields in this special edition, which will link inflammation, immunity, and cancer. We welcome original research papers, reviews, mini-reviews, brief research reports, meta-analyses, clinical studies, and perspective articles addressing, but not limited to:

• The role of chronic and acute inflammation in cancer initiation and progression.
• Immune modulation in the tumor microenvironment, including T cells, myeloid cells, and NK cells.
• The impact of the gut microbiota and other cancer-associated microorganisms.
• Cytokines, chemokines, and their receptors as cancer modulators and therapeutic targets.
• Innovations in immunotherapy and combined therapies with inflammatory modulators.
• Advances in technologies such as genetic editing, organoids, and preclinical models to study inflammation and immunity.
• Biomarkers based on inflammation and immunity for diagnosis, prognosis, and therapeutic response.
• Systemic inflammation and its impact on cancer-related comorbidities.

Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.

Are you interested in contributing a manuscript to this Research Topic?

Inflammation, Immunity, and Cancer: New Pathways Towards Therapeutic Innovation