The rapid evolution of diabetes research and management calls for a forward-thinking approach that embraces innovation to address the multifaceted challenges of this global epidemic. Among the most promising directions are the exploration of gut microbiota as a key player in metabolic and immune regulation and the integration of advanced digital technologies to revolutionize care delivery. While recent studies have highlighted the significant role of gut microbiota in shaping metabolic health, many questions remain unanswered regarding its therapeutic potential in diabetes prevention and treatment.

This research topic aims to explore the intersection of microbiota-targeted interventions and cutting-edge technologies such as AI-driven diagnostics and personalized medicine. In particular, it seeks to advance our understanding of how postbiotics and other microbiotaderived compounds can mitigate complications such as metabolic dysfunction-associated steatotic liver disease and improve metabolic outcomes. Simultaneously, the transformative potential of digital pathology, predictive analytics, and precision tools is poised to redefine the clinical landscape, offering tailored approaches to diabetes care and management.

Key areas of interest include:

• Investigating the mechanistic links between gut microbiota, immune regulation, and diabetes progression.

• Evaluating the efficacy of microbiota-targeted therapies, including postbiotics, in managing metabolic dysfunction and diabetes-related complications.

• Advancing AI-based diagnostic and predictive tools to personalize diabetes care and improve long-term outcomes.

• Exploring the role of biotechnology and digital health solutions in bridging gaps between research discoveries and clinical practice

By integrating insights from microbiology, immunology, digital health, and clinical practice, this research topic seeks to foster innovative strategies that address the growing burden of diabetes and its complications. Submissions are encouraged to offer multidisciplinary perspectives and emphasize the translation of novel findings into impactful clinical applications, supporting the mission to enhance patient outcomes and quality of life.

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Future Horizons in Diabetes: Integrating Gut Microbiota, AI, and Personalized Care