Pulmonary drug delivery represents a rapidly evolving field that holds significant promise for treating respiratory and systemic ailments. The allure of this route stems from its capability to target localized areas, its rapid therapeutic effects, and reduced systemic side effects. Nevertheless, several challenges persist, such as optimizing particle deposition, ensuring drug stability, and overcoming biological barriers in the lungs. Advanced drug delivery systems like nanoparticles, microparticles, and lipid-based carriers are revolutionizing this domain by enabling controlled release, enhancing bioavailability, and achieving precise targeting of therapeutic agents within the respiratory system.

This Research Topic aims to tackle critical challenges and showcase innovative strategies to advance pulmonary drug delivery systems. The topic will delve into the effectiveness of advanced drug delivery platforms in surmounting hurdles such as efficient drug deposition, penetration through lung biological barriers, and ensuring controlled and sustained release. By exploring the utilization of cutting-edge technologies and materials, this Research Topic seeks to emphasize their pivotal role in enhancing therapeutic outcomes and moving toward a more personalized medicine approach in treating conditions like chronic obstructive pulmonary disease (COPD), asthma, and lung cancer.

To gather further insights into the innovative strategies for pulmonary drug delivery systems, we welcome articles addressing, but not limited to, the following themes:

-Nanoparticles, microparticles, and lipid-based carriers for pulmonary delivery
-Aerosol science and optimization of inhalable formulations
-Cyclodextrins and their applications in pulmonary drug delivery
-Microemulsions, micelles, and other nanostructured systems for lung delivery
-Strategies for overcoming lung biological barriers, including mucus penetration and cellular uptake
-Preclinical and clinical studies on pulmonary drug delivery platforms
-Applications of computational modelling and artificial intelligence in designing pulmonary delivery systems
-Safety, toxicity, and regulatory aspects of pulmonary drug delivery systems

The topic editors welcome a variety of article types, such as Original Research, Review, Perspective, Method, or Case Report.

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Advancing Pulmonary Therapeutics with Novel Drug Delivery Technologies