The dynamic cross-talk between metabolism and cellular signaling in the cardiovascular system is crucial for maintaining cellular functionality and homeostasis. Metabolites, once considered mere byproducts, are now recognized for their vital roles in signaling pathways, directly influencing the behaviors of critical cardiovascular cells like endothelial cells, pericytes, macrophages, and cardiomyocytes. Understanding how these metabolites influence signaling pathways is key to decoding the complex mechanisms governing cardiovascular function, disease progression, and potential therapeutic interventions.

Objective:
This Research Topic aims to collate and disseminate pioneering research that investigates the complex interactions at the metabolic/signaling interface in cardiovascular cell regulation. We seek to uncover the roles of specific metabolites within these signaling networks, their effects on cellular interactions, and functions, and their broader implications in cardiovascular health and disease management.

Scope of Research:

Metabolite-Signaling Pathways:
o Exploration of how metabolites modulate signaling pathways within cardiovascular cells.
o Study of the interplay between metabolic processes and signaling networks, focusing on their combined impact on cellular functions.

Intercellular Communication:
o Examination of metabolites as mediators of signaling between various cardiovascular cell types, including mechanistic insights into their roles in modulating cell-cell interactions.

Disease Mechanisms and Progression:
o Analysis of how alterations in metabolic signaling contribute to the onset and progression of cardiovascular diseases.
o Identification of metabolic signatures that could serve as diagnostic or prognostic markers for cardiovascular conditions.

Therapeutic Implications:
o Investigation into the potential of metabolites as targets for therapeutic intervention or as diagnostic biomarkers.
o Development of innovative therapies that target metabolic and signaling pathways to treat cardiovascular diseases.

Call for Contributions:
We invite submissions of original research articles, comprehensive reviews, perspectives, and expert opinions that align with the aforementioned themes. This Research Topic seeks to foster a multidisciplinary dialogue and encourages contributions that blend experimental and theoretical insights, aiming to push the boundaries of our current understanding of the metabolic/signaling interplay in cardiovascular health. Through this collaborative research effort, we aim to explore novel avenues for precision medicine and therapeutic innovations in the cardiovascular field.

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Metabolites and Cell Signaling: Pioneering Advances in Cardiovascular Health