Implants are indispensable tools in modern medicine, enabling the replacement or support of bodily functions in orthopedic, dental, cardiovascular, and neural disciplines. The choice of biomaterials for these implants is crucial, as they need to meet exacting requirements in terms of mechanical properties, chemical stability, and biological compatibility. Historically, materials such as titanium alloys, stainless steel, ceramics like hydroxyapatite and zirconia, and polymers including polyethylene and PEEK have been preferred for their proven reliability and biocompatibility. However, the landscape of implant technology is being transformed by the advent of emerging materials like bioresorbable polymers, hydrogels, nanostructured coatings, and hybrid composites. These novel materials offer enhanced bioactivity, improved antibacterial properties, and controlled degradation rates, opening new possibilities for patient care.

This Research Topic aims to delve into the recent advancements in the field of medical implants, focusing on the development of innovative biomaterials, cutting-edge fabrication techniques, and their implications for clinical practice. The primary objective is to identify and articulate the ways in which these technological innovations can address current challenges in implantology, such as implant rejection, infection, and the long-term wear and tear of implant materials. Through a comprehensive exploration of the latest research, this topic seeks to highlight groundbreaking approaches that enhance the functionality of implants, reduce potential complications, and ultimately lead to better patient outcomes.

To ensure a thorough exploration of this dynamic field, we welcome articles addressing, but not limited to, the following themes:

o Innovative Biomaterials: Development of new metallic, ceramic, polymeric, and composite materials, along with the exploration of bioactive and antimicrobial coatings that enhance the biocompatibility and functionality of implants and the fundamental understanding the biomaterial-living system interactions.

o Advanced (Bio)manufacturing Techniques: Examination of advanced manufacturing techniques, such as 3D (bio)printing, laser machining, electrospinning, and other nanotechnology-based modifications that provide precision and customization in the fabrication of acellular and cellular implants.

o Novel Testing and Computational Modeling: Analysis of the latest methodologies in biomechanical testing, finite element analysis, and the use of artificial intelligence for predictive modeling and simulation to ensure implant safety and efficacy.

o Diverse Applications of Implants: This includes the in vitro and in vivo study of orthopedic implants (e.g., joint replacements, spinal fixtures), dental implants, cardiovascular devices (e.g., stents, pacemakers), neural implants, and the emerging category of bioresorbable implants.

o Clinical Translation and Regulation: Insights into the regulatory landscape, the process of clinical trials, biocompatibility assessments, and the challenges involved in translating these technological advancements from the lab to the clinic.

Topic Editor Professor Stephen Ferguson is the co-founder of CustomSurg AG. The other Topic Editors declare no competing interests regarding the Research Topic subject.

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Advances in Biomaterials and (Bio)fabrication for Medical Implants