Heart Failure with Preserved Ejection Fraction (HFpEF) represents a significant aspect of cardiovascular research due to its complex nature and rising prevalence amongst the elderly, most notably those with conditions such as hypertension, obesity, and diabetes. Unlike Heart Failure with Reduced Ejection Fraction (HFrEF), HFpEF is characterized by a normal left ventricular ejection fraction, creating notable challenges in accurate diagnosis and effective treatment. Current research is increasingly focused on understanding the diverse pathophysiological mechanisms of HFpEF, including systemic inflammation, endothelial dysfunction, myocardial stiffness, and metabolic irregularities. These insights are driving a transition from generalized clinical approaches to more precise, phenotype-specific management strategies. State-of-the-art developments like imaging technologies, biomarker advancements, and machine learning are pivotal in refining patient stratification and risk assessment, highlighting the need for multidisciplinary investigation and individualized patient care.

This Research Topic aims to investigate the new paradigms emerging in the comprehension and management of Heart Failure with Preserved Ejection Fraction (HFpEF), with a particular emphasis on the evolution from conventional pathophysiological understanding to tailored treatment methodologies. The objective is to examine recent advances in understanding disease mechanisms, implementing diagnostic innovations, and employing patient stratification techniques, with the ultimate goal of devising novel strategies to enhance clinical outcomes. By exploring these contemporary advancements, the research seeks to contribute to the burgeoning framework of HFpEF care through the promotion of precision medicine, specifically adapted to individual patient profiles.

To gather further insights in the classification and management of HFpEF, we welcome articles addressing, but not limited to, the following themes:

• Classification and phenotyping of HFpEF

• The role and impact of comorbidities on HFpEF outcomes

• Advances in biomarkers and imaging technologies

• Recent clinical trials focusing on personalized treatments for HFpEF

• The application of precision medicine in adult HFpEF cases

This Research Topic primarily focuses on adult populations, emphasizing the elderly demographic, and does not encompass pediatric heart failure or non-cardiac etiologies of preserved ejection fraction.

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Redefining Heart Failure: Personalized Treatment Paradigms for HFpEF