This Research Topic is the second volume of the “Crosstalk in Ferroptosis, Immunity & Inflammation” Community Series. Please see Volume I here

Ferroptosis represents a critical form of regulated cell death, notable for its reliance on iron and its triggering by lipid peroxidation. The process becomes particularly significant in the context of inflammation, a crucial bodily response intended to tackle various threats and ensure tissue equilibrium. Issues arise when inflammation is uncontrolled, leading towards immune dysfunction and cellular demise. Current studies have further postulated that inflammation may instigate ferroptosis, releasing damage-associated molecular patterns (DAMPs) that activate the immune response and exacerbate inflammation. This bi-directional relationship highlights a complex interplay where ferroptosis and inflammation are both cause and consequence.

This Research Topic aims to delineate the complex interactions between ferroptosis and inflammation, uncovering how this nexus influences disease treatment, particularly in inflammatory diseases and cancers. We intend to dissect the interaction between ferroptosis and various immune cells and assess ferroptosis's role in conditions like infection, inflammation, and cancer. These insights are anticipated to reveal novel therapeutic avenues and advance the development of targeted medicinal interventions.

We welcome submissions of Original Research, Methods, Brief Research Reports, Review and Mini-Review Articles that address a variety of sub-topics, with a focus on the following areas:

1. Ferroptosis and immune response (including ferroptosis-related inflammatory factors, DAMPs-induced cellular immune response)
2. Ferroptosis and inflammatory diseases
3. Ferroptosis and lipid metabolism
4. Targeted ferroptosis-related immunotherapy
5. Ferroptosis and organ damage
6. Ferroptosis and inflammation
7. Regulatory genes associated with ferroptosis and inflammation
8. Development and application of ferroptosis inhibitors and inducers
9. Ferroptosis and inflammatory signal transduction pathway
10. Ferroptosis and homeostasis of cellular oxidative stress

Please note that manuscripts without a major focus on immunology are out of scope for this Research Topic as well as for this journal.

Are you interested in contributing a manuscript to this Research Topic?

Community Series in Crosstalk in Ferroptosis, Immunity & Inflammation: Volume II

Topic Coordinator