Aging gut microbiota and intestinal mucosal layer, including immune cells alter host physiology and enhance the prevalence of various health issues. These effects may be due to dysbiosis, dysfunctional immune function, and activation of inflammatory cytokines resulting in silent low-grade inflammation. Aging dysbiosis leads to metabolic disorders in various cellular systems and is one of the major factors of metabolic syndromes such as obesity, atherosclerosis, insulin resistance, glucose intolerance including local inflammatory diseases, and IBD to systemic inflammatory disorder and cancer. Aging gut microbiota-induced metabolic disorders increase the aging of host cells and affect the overall life of the individual. Aging gut microbiota and mucosal immunology affect the Central Nervous System function by altering the gut-brain axis. This may lead to various chronic neuroinflammatory disorders such as Alzheimer’s disease. Similarly, aging gut microbiota may affect cardiovascular function that provokes age-related cardiovascular dysfunctions in individuals. Thus, aging microbiota may alter the homeostasis of the immune system and lead to CNS, cardiovascular and metabolic dysfunction, etc.

Our goal is to collect research information on various diseases and immunological disorders induced by aged microbiota and downstream cellular signaling. It is important to know how aged microbiota affects intestinal cellular immunology and thereafter interactions with various organs to alter their homeostasis and pathophysiological mechanisms. These research articles will highlight the various new therapeutic targets for metabolic as well as CNS diseases provoked by aged gut microbiota.

Under this umbrella topic, we would like to invite different scientists and research scholars working in aging microbiota and intestinal immunology. That also includes a molecular mechanism and cellular signaling of aging microbiota and its effects in metabolic syndromes, including epigenetics and other responses. This Research Topic will include novel research in the field of aging gut microbiota and related articles.

We welcome manuscripts including review articles, mini-reviews, and case reports covering the following (but not limited to) topics:

•Aging microbiota and inflammatory disease
•Aged gut microbiota and metabolic disease
•Microbiota and intestinal barrier dysfunction

Are you interested in contributing a manuscript to this Research Topic?

Impact of Aging Gut Microbiota and Mucosal Immunology in Health