Cancer and metabolic diseases, such as obesity, diabetes, and metabolic syndrome, are increasingly recognized as interconnected conditions with shared underlying mechanisms. Metabolic reprogramming in cancer cells, chronic inflammation, insulin resistance, and oxidative stress are key factors that link these diseases. The Warburg effect, glutaminolysis, and altered fatty acid metabolism in cancer cells, along with the inflammatory and metabolic dysregulation seen in obesity and diabetes, create a tumor-permissive microenvironment. Understanding these complex interactions is crucial for developing effective prevention and treatment strategies for both cancer and metabolic disorders.

The goal of this Research Topic is to explore the intricate molecular, cellular, and systemic mechanisms that link cancer and metabolic diseases. We aim to highlight the bidirectional influence of metabolic dysfunction and cancer progression, emphasizing shared pathways such as inflammation, insulin resistance, and metabolic reprogramming. By bringing together cutting-edge research, we seek to identify novel therapeutic targets and interventions that address both cancer and metabolic diseases simultaneously. This Research Topic will provide a comprehensive overview of the current understanding of these interconnected conditions and offer insights into future research directions.

This Research Topic invites contributions that explore the molecular and cellular mechanisms linking cancer and metabolic diseases, with a focus on shared pathways such as metabolic reprogramming, inflammation, insulin resistance, and oxidative stress. We encourage submissions that investigate the role of lifestyle factors (e.g., diet, physical activity, smoking) in the development of both conditions and explore potential therapeutic interventions, including metabolic inhibitors and lifestyle modifications. Specific themes of interest include:

• Metabolic reprogramming in cancer (e.g., Warburg effect, glutaminolysis, fatty acid synthesis).

• The role of obesity-induced inflammation and insulin resistance in cancer progression.

• The impact of diabetes and hyperglycemia on tumorigenesis.

• Shared risk factors (e.g., diet, physical inactivity, smoking) and their contribution to both cancer and metabolic diseases.

• Novel therapeutic strategies targeting metabolic pathways in cancer and metabolic diseases.

• Integrated approaches combining lifestyle interventions with pharmacological treatments.

We welcome a variety of manuscript types, including original research articles, reviews, mini-reviews, and perspectives that provide new insights into the mechanisms linking cancer and metabolic diseases. Submissions should aim to advance our understanding of these interconnected conditions and contribute to the development of effective prevention and treatment strategies.

Are you interested in contributing a manuscript to this Research Topic?

Mechanisms Linking Cancer and Metabolic Diseases: From Molecular Pathways to Therapeutic Interventions