About this Research Topic
Sleep comprises one third of the human lifespan. Significant metabolic and hormonal changes occur during healthy sleep. Seminal studies have demonstrated sleep-specific metabolic changes such as reductions in body temperature, energy expenditure, glucose turnover, lipolysis, and increases in growth hormone and prolactin. These metabolic changes are further influenced by activity, age, disease, diet, circadian rhythm, or the presence of sleep disorders. Abnormal sleep – as might be observed in conditions such as circadian rhythm disorders, long/short sleep duration, insomnia, sleep apnea, or restless leg syndrome may also have independent impacts on metabolic or hormonal function. Furthermore, endocrinopathies such as diabetes or thyroid disorders can affect sleep-related metabolism, or sleep itself. These changes may manifest as outcomes such as insulin resistance, obesity, or inflammation. Thus, healthy sleep is paramount to metabolic function, and abnormal metabolism during sleep can be a manifestation of an endocrine disorder.
This Research Topic invites clinical science, basic science, and review articles that address:
• Sleep metabolic physiology: How does healthy sleep affect whole-body, tissue, or cellular metabolism? What are the effects of variables such as age, sex, diet, obesity, activity, or exercise on metabolic function during sleep? Outcomes may include energy expenditure, weight gain, appetite, substrate utilization, hormones, genetic/epigenetics, and signaling pathways.
• Sleep-related metabolic pathology: How do sleep disorders affect whole-body, tissue, or cellular metabolism? For example, what are the metabolic consequences of altered circadian rhythm, long/short sleep duration, insomnia, sleep apnea, or restless leg syndrome? What are the underlying mechanisms of these impacts? As above, outcomes may include energy expenditure, weight gain, appetite, substrate utilization, hormones, genetic/epigenetics, and signaling pathways.
• Sleep as a window into endocrine disease: What are the impacts of endocrine disorders such as diabetes, Cushing’s syndrome, acromegaly, thyroid dysfunction, or eating disorders on sleep quality or architecture? Can sleep be useful for assessing metabolic health?
• Therapeutic interventions to improve metabolic health through sleep: Are there known or novel pathways that can be targeted during sleep to improve overall cardio-metabolic health?
Keywords: Sleep, metabolism, diabetes, apnea, circadian
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