Mechanical circulatory support (MCS) and cardiac transplantation are pivotal interventions required to manage the increasing global challenge of advanced heart failure. Despite significant technological advancements in MCS devices and innovations in transplantation protocols, disparities in access to these life-saving interventions, inconsistent outcomes, and varying standards of post-operative care continue to exist worldwide. Recent research highlights the potential of next-generation ventricular assist devices, innovative donor heart preservation techniques, and novel immunosuppressive therapies. These advancements hold promise for enhancing patient survival rates and improving the quality of life of heart failure patients globally.

This Research Topic aims to bring together multidisciplinary perspectives, investigate regional advancements, and identify opportunities to optimize mechanical circulatory support and cardiac transplantation through a global lens. By doing so, it hopes to unravel the complexities of heart failure management and propose solutions that can transform these robust therapies into universally accessible options.

The research encompasses a range of topics essential to improving global outcomes for heart failure therapies. We welcome articles addressing, but not limited to, the following themes:
• Advances in mechanical circulatory support devices focusing on innovation, durability, and patient outcomes
• Strategies for enhancing donor heart preservation and transportation for successful transplantation
• Role of artificial intelligence in predicting outcomes and optimizing care in MCS and transplantation
• Global disparities in access to mechanical circulatory support and cardiac transplantation
• Emerging immunosuppressive therapies and personalized medicine for post-transplant care
• Approaches to reduce complications and enhance the quality of life in MCS recipients
• Cross-regional collaboration and knowledge sharing for standardizing heart failure management practices
• Impact of minimally invasive techniques on bridging therapies for cardiac transplantation

By bridging knowledge gaps and fostering collaboration among heart failure specialists, researchers, and clinicians worldwide, this collection aims to accelerate the development of equitable and transformative solutions in global cardiovascular care.

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Transforming heart failure management: Global perspectives on mechanical circulatory support and transplantation