B cells play a central role in autoimmune diseases, acting as both antibody producers and antigen-presenting cells while contributing to immune regulation. Their dysregulation can lead to the loss of tolerance, excessive production of autoantibodies, and aberrant cytokine secretion, all of which drive autoimmune pathology. The complex interplay between B cells and other immune cells, including T cells, dendritic cells, and macrophages, further amplifies immune dysregulation. Advances in understanding B cell subsets, signaling pathways, and metabolic reprogramming have provided new insights into their pathogenic role and therapeutic targeting in autoimmune diseases.

This Research Topic will investigate targeted and effective treatments for autoimmune diseases by leveraging cutting-edge technological interventions in B cell subset modulation. Expanding upon current knowledge, this Research Topic will drive innovation by integrating novel therapeutic approaches, including advanced biologics and tailored treatment protocols, aimed specifically at the peculiarities of B cell pathogenic mechanisms in autoimmune conditions.

To gather further insights into this field, the Topic Editors welcome articles addressing, but not limited to, the following themes:

1. The role of B cell populations and subsets in the pathogenesis of autoimmune diseases.

2. Mechanisms of autoantibody generation and epitope spreading in autoimmunity.

3. B cell interactions with other immune cells and the role of B cells in antigen presentation in health and disease.

4. Cytokine signaling in B cell biology in the pathogenesis of autoimmune diseases.

5. CRISPR-Cas9 applications in B cell gene editing.

6. Advances in flow cytometry for B cell sorting.

7. Development of novel biologics and therapeutic approaches that target B cell receptors and their signaling pathways.

8. Implementation of personalized medicine strategies in autoimmune disease treatment.

9. Patient-specific immune profiling and the design of tailored therapeutic regimens.

Additionally, the Topic Editors encourage authors to explore the potential of personalized medicine approaches, including patient-specific immune profiling and tailored therapeutic regimens. By focusing on the central role of B cells in autoimmunity, this Research Topic will develop targeted and effective treatments for autoimmune diseases. We encourage submissions of both original research, review articles, and exceptional case reports on this topic.

Topic Editor Chris Wincup retains a consultancy role with Abbvie and Gilead, is on the advisory board with Biogen, is in receipt of an honorarium from various companies, and is in receipt of research funding paid to institution from AstraZeneca, Versus Arthritis, Lupus UK and Lupus Foundation of America. Topic Editor Peter Korsten has received honoraria or travel support from various companies, all unrelated to this Research Topic, and has received research grants from GlaxoSmithKline and Diamed Medizintechnik GmbH, again unrelated to this Research Topic. Topic Editor Mariele Gatto is in receipt of honoraria from GSK, BMS and Astrazeneca.

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Modulating B cell subsets: Future therapeutics for autoimmune diseases