About this Research Topic
Changes in the epigenetic features, which occur without alterations in DNA sequence, are sufficient to regulate gene expression. Epigenetic mechanisms have been associated with normal embryogenesis and their aberrations can be involved in numerous pathologies including cancer, the regulation of inflammation, rheumatic diseases, and cardiovascular disorders among others. Thus, they are being considered as potential therapeutic targets. Complementary approaches such as, to name a few, natural phytochemicals, mechanical stress, pulse magnetic field including nanomagnetic particles appear to modulate mammalian epigenome through chromatin remodeling. Phytochemicals whether present in our diet or food supplements are used for prevention or treatment of many diseases such as, but not limited to cancer, Parkinson's, anti-inflammatory actions, Alzheimer's, preventing cataract and retaining a healthy heart.
A growing body of research indicates that those powerful antioxidants, i.e., the polyphenol present in fruits, green tea, curcumin, and soybean isoflavones acquire anticancer activities by modulating the patient epigenome leading to the inhibition of a proto-oncogene or the activation of a tumor suppressor. Moreover, mechanical stress is found to promote cell death and is suggested as a complementary application for cancer treatment. Pulse magnetic field stimulation is also proposed as an adjuvant treatment to various cancer types. Needless to say, epigenetic modulations will allow the development of novel biomarkers for disease activity, and response to treatment.
Although recent advances in the fields of natural phytochemicals and other forms of either alternative or complementary method of disease treatment are on the rise; more profound studies are still needed to understand better the effects of these natural phytochemicals and other forms of either alternative or complementary method and their contribution in targeting the epigenetic aberrations. The "Epigenetic Modulating Agents: Complementary and Alternative Treatment Approaches" will provide a forum for publishing and be discussing new developments in the field.
Keywords: Complementary treatment, Alternative treatment, Epigenetic, Modulating agent
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