Plant diseases continue to pose a significant threat to global agriculture, leading to substantial losses in crop yield and quality. As the global population rises and climate change alters environmental conditions, the urgency for sustainable and innovative strategies to manage plant diseases intensifies. A deeper understanding of host-pathogen interactions presents a critical opportunity to develop effective, durable plant protection approaches.

These interactions are governed by complex molecular and ecological mechanisms, which underlie both disease progression and resistance in plants. Advances in research have highlighted a variety of innovative control strategies, including the use of peptides, biopolymers, plant specialized metabolites, microbial compounds, RNA interference (RNAi), essential oils, nanoparticles, and biological control agents (BCAs). In parallel, plant breeding—enhanced by new breeding techniques—offers a promising avenue for developing crops with increased resistance or tolerance to biotic stresses.

Although many of these strategies have demonstrated effectiveness in both in vitro and in vivo settings, their broader application is often limited by insufficient assessments of environmental impact and toxicological safety. This disconnect underscores the need for integrative research that bridges laboratory innovation with real-world implementation.

This Research Topic aims to connect cutting-edge developments in plant pathology, molecular biology, and agricultural technology. By focusing on host-pathogen interactions, the collection seeks to uncover novel protective molecules and reveal the underlying mechanisms driving plant resistance.

Emphasizing a multidisciplinary approach, the topic incorporates state-of-the-art technologies such as CRISPR-based gene editing, OMICs tools including metabolomics and next-generation sequencing (NGS), and precision agriculture techniques alongside emerging biocontrol solutions. Through elucidating the mechanisms of action and evaluating scalability and environmental impact, this collection aspires to provide transformative insights.

Ultimately, it strives to promote practical, sustainable strategies that address the urgent challenges of plant disease management and contribute to building resilient agricultural systems.

We welcome submissions on, but not limited to, the below:

- Investigate molecular and ecological mechanisms of host-pathogen interactions

- Identify and characterize novel plant-protective compounds and resistance traits

- Explore sustainable disease control strategies, including biological agents and natural products

- Evaluate the environmental and toxicological impact of innovative plant protection methods

- Integrate advanced tools such as CRISPR, OMICs (e.g., metabolomics, transcriptomics), and precision agriculture

- Demonstrate the scalability and real-world application of promising plant disease management solutions

Are you interested in contributing a manuscript to this Research Topic?

Innovative Strategies for Managing Plant Disease: Lessons from Host-Pathogen Interactions