The field of bioengineering and regenerative medicine is experiencing significant advancements with the integration of novel fabrication techniques and biomaterials for assembling in vitro multicellular systems. These developments hold the potential to closely mimic the structural and functional intricacies of native tissues and organs, playing a vital role in biological studies, drug screening, and regenerative therapies. The advent of fabrication methodologies, such as bioprinting and microfluidics, has significantly impacted in vitro tissue model construction, enabling the design of intricate tissue structures with meticulous control over their microenvironment.

A critical element in the success of these fabrication techniques is the strategic design and choice of biomaterials supporting cellular functions like adhesion, proliferation, and differentiation. Progress in biomaterial engineering has resulted in bio-inks, hydrogels, and scaffolds with remarkable biocompatibility and mechanical characteristics. The incorporation of bioactive molecules and smart biomaterials with adaptive responses further enhances the cellular dynamics and tissue formation, providing fertile ground for dynamic tissue engineering.

This Research Topic aims to investigate advanced fabrication methodologies alongside biomaterial innovations that facilitate the assembly of multicellular systems in a manner that authentically replicates physiological environments and cellular interactions. To achieve these objectives, this research endeavors to bridge gaps related to long-term cultures, vascularization, and accurate mechanical microenvironment replication. The pursuit of green and sustainable alternatives to traditional methods is integral. We invite contributions showcasing breakthroughs, interdisciplinary innovations, and sustainable biomaterial strategies in the assembly of in vitro multicellular systems spanning co-culture, organoids, and organ-on-chip structures.

To gather further insights in this multidisciplinary field, we welcome articles addressing, but not limited to, the following themes:
o Innovative biomaterials applied to multicellular systems (e.g., co-cultures, organoids, spheroids, organ-on-chip)
o Sustainable biomaterials for microfluidic applications
o Advanced fabrication techniques for in vitro modelling (e.g., electrospinning, photolithography)
o Decellularized scaffolds for tissue engineering
o Utilization of 3D printing technologies for tissue modeling
o Development of organoids and spheroids utilizing 3D biomaterial-based scaffolds
o Smart biomaterials enhancing tissue engineering approaches

This comprehensive Research Topic aims to present contemporary perspectives on cutting-edge strategies for assembling in vitro multicellular systems, fostering interdisciplinary collaboration in advancing sustainable approaches for biomedical engineering.

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Advanced Fabrication Techniques and Biomaterials for the Assembly of In Vitro Multicellular Systems