Researchers worldwide were encouraged to focus on improving awareness, understanding, and surveillance of Antimicrobial Resistance (AMR) in addition to developing mitigation measures to reduce the use of antibiotic drugs for human and animal health. Probiotics, defined as “live microorganisms which when administered in adequate amounts confer a health benefit to the host”, have routinely been suggested as antibiotic alternatives for a variety of human and animal disease states and conditions.

This Research Topic encourages studies that highlight the molecular, cellular and physiological mechanisms through which probiotics and postbiotics exert their beneficial effects.

We welcome contributions that provide insights into the development and application of novel probiotic strains and their metabolites (small molecules, bacteriocins, peptides, etc.), evaluate their efficacy in different animal and human health environments, and identify challenges and solutions for their implementation.

The scope of this Research Topic includes, but is not limited to, the following sub-themes:

• The impact of probiotics on the animal or human gut microbiome and resistome

• Mechanistic studies on how probiotics confer health benefits on the host, including enhanced immune response and disease resistance

• Probiotics and postbiotics as alternatives of antibiotic therapy

• The antimicrobial compounds produced by lactic acid bacteria (LAB), Bacillus subtilis and other GRAS microorganisms

• The eventual medical applications of LAB and GRAS microorganisms derived antimicrobials

• Safety aspects of probiotics and their metabolites

In this Research Topic we welcome the following article types: Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Systematic Review, Technology and Code.

Are you interested in contributing a manuscript to this Research Topic?

Microbial Metabolites to Combat Antimicrobial Resistance