Research Topic

Systems Biology of Metabolism in Infections

About this Research Topic

Pathogenic microorganisms have a primary goal of exploiting the metabolites of the host cells by ma-nipulating the host metabolism. They can rewire the metabolic interactions of the host with the major objective of sustained survival. Host cells, on the other hand, try to prevent the disruption caused by pathogens in their metabolic networks. Thus, several metabolic changes are induced in both pathogen and host sides in the course of infection. Understanding these alterations is crucial to develop novel diagnostics and treatment strategies for infectious diseases.

Therefore, systems biology approach is commonly used to elucidate the effect of infection on cell metabolism and to identify potential bi-omarkers and drug targets. Therefore, the following themes will be covered in this Research Topic:

- Constraint-based reconstruction and analysis of genome-scale metabolic networks for infection research
- Structure-based and sequence-based analysis of enzymes derived from metabolic pathway comparisons
- Metabolomics and fluxomics in infection research
- Data mining and statistics in infection research to identify metabolism-derived bi-omarker and drug target candidates


Keywords: Systems Biology, Metabolic Interaction Network, Pathogen-Host Interaction, Constraint-based analysis, Structure-based analysis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Pathogenic microorganisms have a primary goal of exploiting the metabolites of the host cells by ma-nipulating the host metabolism. They can rewire the metabolic interactions of the host with the major objective of sustained survival. Host cells, on the other hand, try to prevent the disruption caused by pathogens in their metabolic networks. Thus, several metabolic changes are induced in both pathogen and host sides in the course of infection. Understanding these alterations is crucial to develop novel diagnostics and treatment strategies for infectious diseases.

Therefore, systems biology approach is commonly used to elucidate the effect of infection on cell metabolism and to identify potential bi-omarkers and drug targets. Therefore, the following themes will be covered in this Research Topic:

- Constraint-based reconstruction and analysis of genome-scale metabolic networks for infection research
- Structure-based and sequence-based analysis of enzymes derived from metabolic pathway comparisons
- Metabolomics and fluxomics in infection research
- Data mining and statistics in infection research to identify metabolism-derived bi-omarker and drug target candidates


Keywords: Systems Biology, Metabolic Interaction Network, Pathogen-Host Interaction, Constraint-based analysis, Structure-based analysis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

01 May 2018 Abstract
01 October 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

01 May 2018 Abstract
01 October 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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