The study of the tumor microenvironment in the liver is a rapidly advancing field that holds significant potential for improving therapeutic strategies against liver cancer. The liver's unique microenvironment, marked by molecular regulation and complex phenotypes, significantly influences tumorigenesis and the recurrence of liver cancer. Understanding these interactions is crucial, as current therapeutic interventions often face challenges in preventing liver cancer recurrence. Recent studies highlight the intricate molecular interactions within the liver microenvironment and their role in sustaining malignancy. Despite advancements, gaps remain in comprehensively understanding the microenvironmental factors driving tumor progression and recurrence, emphasizing the necessity for innovative discoveries in this area.

This Research Topic aims to uncover and explain the mechanisms underlying the incidence and postoperative recurrence of liver cancers, with a focus on the tumor microenvironment of liver cancers, especially hepatocellular carcinoma. By bridging fundamental research with clinical studies, this topic seeks to answer critical questions about how microenvironmental changes can be targeted to prevent recurrence and improve patient outcomes. An emphasis is placed on exploring molecular mechanisms, identifying promising therapeutic targets, and devising new treatment strategies to combat tumor progression.

To gather further insights in the field of hepatocellular carcinoma related to the tumor microenvironment, we welcome articles addressing, but not limited to, the following themes:

• Molecular regulation within the liver microenvironment impacting tumor progression in the liver
• Changes in the liver microenvironment associated with postoperative recurrence
• Identification of novel therapeutic targets within the tumor microenvironment
• The interplay between systemic anti-tumor therapies and the liver microenvironment
• Clinical interventions targeting microenvironmental factors in tumor recurrence
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.

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Novel Insights into the Tumor Microenvironment's Role in Liver Cancer Occurrence and Recurrence