Neuroimaging has revolutionized our understanding of the brain, enabling the visualization of structure, function, and connectivity across multiple spatial and temporal scales. However, the growing volume and complexity of neuroimaging data—generated from techniques like fMRI, EEG, MEG, and diffusion imaging—pose significant analytical challenges. Data mining has emerged as a powerful solution, offering techniques to uncover patterns, relationships, and insights that may not be evident through traditional analysis methods. By leveraging machine learning, statistical modeling, and advanced computational algorithms, data mining enables researchers to decode brain activity, classify disorders, and predict cognitive or behavioral outcomes. As the field evolves, there is a growing need to refine and evaluate these techniques, ensuring robust, interpretable, and generalizable findings. This Research Topic will explore cutting-edge approaches in neuroimaging data mining, aiming to advance our ability to extract meaningful knowledge from complex brain data and support breakthroughs in neuroscience and clinical research.

The explosion of neuroimaging data from modalities such as fMRI, EEG, MEG, and diffusion imaging presents both immense opportunities and significant challenges. While these datasets offer rich insights into brain structure and function, their high dimensionality, noise, and variability across individuals make analysis complex. Traditional statistical approaches often fall short in capturing subtle, nonlinear patterns within the data. This is where data mining becomes essential—offering powerful tools to extract meaningful features, detect hidden structures, and build predictive models.Recent advances in machine learning, deep learning, and multivariate analysis have enhanced the ability to mine neuroimaging data for biomarkers, disease classification, and brain-behavior relationships. However, key challenges remain in ensuring reproducibility, interpretability, and generalizability of results across datasets and populations.

This Research Topic aims to address these issues by highlighting innovative data mining techniques in neuroimaging. We seek contributions that introduce novel methods, compare existing approaches, or demonstrate applications in cognitive neuroscience and clinical diagnostics. Emphasis will be placed on methods that improve accuracy, scalability, and insight into the brain’s complex dynamics.

This Research Topic invites all papers focused on data mining techniques applied to neuroimaging. We welcome contributions that explore machine learning, deep learning, clustering, feature extraction, and dimensionality reduction methods for analyzing data from modalities such as fMRI, EEG, MEG, and diffusion imaging. Specific themes include classification and prediction of neurological or psychiatric conditions, brain-behavior mapping, functional connectivity analysis, and multi-modal data integration. Submissions that address challenges like data heterogeneity, interpretability, reproducibility, and model generalization are particularly encouraged. We are also interested in benchmarking studies comparing different data mining approaches and in papers that present novel tools or frameworks for large-scale neuroimaging analysis. This topic aims to showcase state-of-the-art techniques and foster advancements in how we extract meaningful patterns from complex brain data, supporting both basic neuroscience and translational applications in clinical research. Interdisciplinary work combining neuroscience, computer science, and data science is highly encouraged.

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Data Mining in Neuroimaging