In the realm of cardiovascular therapy, tissue engineering and regenerative medicine have emerged as promising frontiers to tackle the high morbidity and mortality rates of cardiovascular diseases (CVDs). Traditional pharmacological and surgical interventions are often insufficient, igniting a demand for innovative therapeutic approaches. Biopolymer-based scaffolds, alongside advanced 3D cell culture systems and stem cell therapies, represent a significant leap forward in this field. Researchers are particularly interested in biopolymers like collagen, gelatin, and fibrin, due to their ability to mimic the cellular environment necessary for cellular attachment, survival, and differentiation. Through 3D fabrication technologies, such as bioprinting, engineered vascular structures have been developed, mirroring native cardiovascular systems and offering potential remedies for vascular reconstruction and repair following ischemic events.

This Research Topic aims to focus on cutting-edge progress in biopolymer scaffold design, 3D culture systems, and cell-loaded vascular constructs pivotal for cardiovascular regeneration. It will explore avenues where biomaterials science, vascular biology, and regenerative therapies converge to confront existing obstacles in clinical application and facilitate a deeper understanding of the potential clinical benefits. By accumulating original research, reviews, and expert perspectives, this topic endeavors to unveils new therapeutic pathways, ultimately enhancing patient care for those with vascular and cardiac conditions.

To gather further insights into the range and challenges of biopolymer-based constructs in cardio-regenerative medicine, we welcome articles addressing, but not limited to, the following themes:

- Engineering of biomimetic collagen, gelatin, fibrin hydrogels for cardiovascular uses.
- Innovative strategies for adjusting properties of biopolymer scaffolds.
- Techniques in 3D bioprinting for fabricating vascular structures.
- Development and integration of 3D culture systems and stem cell technologies.
- Creation and assessment of small-diameter vascular grafts.
- Implementation of novel endothelialization methods for graft improvement.
- Advancements in preclinical applications and clinical translation pursuits.
- Immunomodulation potential in cardiovascular biopolymer applications.
- Incorporation of AI in the design and refinement of biopolymer constructs.

The research output is expected to include various types of articles, such as original research, reviews, and perspectives

Are you interested in contributing a manuscript to this Research Topic?

Biopolymer-Based 3D Constructs and Stem Cell Strategies for Cardiovascular Regeneration