The interplay between immune-system and the cardiovascular system, specifically the relationship between inflammatory molecules and the determinants of cardiovascular function is vital in maintenance of fitness and health including during rest and strenuous physical activity. Innate and adaptive immune responses contribute to the onset and progression of acute coronary events, cardiac arrhythmias, inflammatory cardiac conditions and heart failure. Immune responses play critical roles in specific clinical setting such as Allo-immunity after heart transplantation as well as inflammatory patterns in multi-organ dysfunction, depression and other mood states and during cardiovascular implications of post-acute sequelae of COVID. However, the interplay and relationship between inflammatory molecules and the key determinants of cardiovascular function preload, afterload, contractility and rhythm has not been systematically reviewed.

Goal:

Research on the interplay between the immune system and cardiovascular function, health and disease employs a variety of methodologies, ranging from basic science techniques to study 1) mechanisms 2) cutting-edge translational relationships and 3) clinical approaches in humans. In the research topic, we bring together world -renowned research teams to provide systematic insights into these relationships.

Scope for the authors:

To gather further insights within the context of immune-cardiovascular interactions in physiological and pathological scenarios, we welcome articles Original Research, Systematic Review, Review and Mini-Review, Hypothesis & Theory, Clinical Trials focusing on, but not limited to, the following sub-topics:

• Immune system interactions with determinants of cardiovascular function (preload, afterload, contractility, and rhythm) in health and during physical activity

• Immune system interactions with determinants of cardiovascular function (preload, afterload, contractility, and rhythm) in cardiac dysfunction

• Clinical implications of inflammatory mechanisms driving the onset and progression of cardiac diseases, including acute coronary syndromes, arrhythmias, myocarditis, cardiomyopathy, and heart failure

• Clinical implications of immune-mediated cardiovascular disorders post-heart transplantation

• Role of systemic inflammation linked to mood disorders in cardiovascular and multi-organ dysfunction syndromes

• Cardiovascular consequences of immune and inflammatory pathways in post-acute COVID-19 syndromes

• Role of immune systems in frailty and cardiovascular outcomes

• Immunomodulation and cardiovascular disease

Topic editor Mario C. Deng is CareDx Consulting reAlloMap Heart Transplant Rejection Blood test. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

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Immune-Cardiac Axis: exploring immune response interactions with cardiovascular function in health and disease