Cutaneous involvement account for the majority of drug-related adverse events. During recent years the introduction of novel and advanced target therapies represented a game-changing therapeutic advancement in many fields of medicine. On the other side, novel cutaneous adverse events were reported and associated to novel therapies (e.g. paradoxical reactions to biologic drugs, immune checkpoint inhibitor dermatological manifestation and so on). This represented an opportunity to further unravel the pathophysiology of many skin diseases but also and most importantly a diagnostic and therapeutic challenge for clinicians in order to manage the adverse events while treating the primary disease.

The goal of the present Research Topic is to gather and summarize recent evidence on the drug-induced and related dermatological manifestations, both for classical drugs and for novel therapies.

The primary objective includes the description of novel observations related to drug cutaneous adverse events and the therapeutic management of these condition, but also the identification of clinical and molecular biomarker in order to identify patients at risk to develop the above-mentioned manifestations.

To gather further insights into this topic we welcome articles addressing, but not limited to, the following themes:

- Dermatological paradoxical reactions to biologic therapies
- Immunotherapy inhibitor induced (ICI) dermatological manifestations
- Immune and non-immune cutaneous drug reactions, including lichenoid drug-reaction, drug-induced immunobullous disorders, photo-induced drug reactions…
- Skin appendage (hair and nails) adverse events
- Pigmentary disorders secondary to drug exposure
- Therapeutic management of cutaneous related adverse events
- Cutaneous skin prevention and adverse events management in the oncological patients
- Possible clinical, molecular and genetic biomarkers predicting a cutaneous related adverse event onset

The following article types are welcome for submission, including:
• Brief Research Report
• Original Research
• Review
• Mini Review
• Systematic Review
• Case Report
• Perspective
• Data report
• General Commentary
• Hypothesis and Theory
• Classification

Are you interested in contributing a manuscript to this Research Topic?

Exploring Cutaneous Drug-Related and Drug-Associated Adverse Events: From Clinical Insight to Therapeutic Management