Headache and cerebrovascular diseases signify substantial health burdens worldwide and a complex interplay between these conditions remains understudied. Researchers have long been intrigued by the potential linkages between headache syndromes, such as migraines, and cerebrovascular incidents, like strokes and intracranial aneurysms. Despite advances in imaging and genetic research, the molecular pathways and pathophysiological processes bridging these two medical phenomena remain unclear. Contemporary studies underline the importance of examining genetic factors, regulatory pathways, and biomarkers that could illuminate these associations while tackling factors like neurovascular coupling and inflammatory responses. The ongoing debates and studies highlight a pressing need for an integrated investigation into these coexisting medical issues, potentially unlocking new diagnostic and therapeutic avenues.

This Research Topic aims to systematically review the multifaceted interactions between headache disorders and cerebrovascular diseases. By delving into genetic analysis, transcriptomics, and clinical exploration, the intent is to shed light on essential gene loci, regulatory pathways, and biomarkers. Furthermore, the topic seeks to evaluate the utility of advanced imaging techniques in uncovering the correlations, explore headache as an early warning sign, and assess innovative treatment approaches like neuromodulation and drug interventions. Ultimately, the goal is to build a comprehensive theoretical and practical framework enhancing precise diagnosis, treatment, and prevention strategies.

To gather further insights into the intersection of headaches and cerebrovascular diseases, we welcome articles addressing, but not limited to, the following themes:

- Genetic and transcriptomic analyses for key gene loci and biomarkers

- Pathophysiological mechanisms linking headaches and cerebrovascular diseases

- Roles of vasoactive substances and inflammation in disease development

- Cutting-edge imaging techniques revealing disease associations

- Identifying headache as a predictive marker for cerebrovascular incidents

- Innovative treatment strategies and clinical efficacy evaluations

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Research on the Correlative Mechanisms and Clinical Exploration of Headache and Cerebrovascular Diseases